Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
1_MQRSP 6_ LEKAS 11_ VVSKL 16_ FFSWT 21_ RPILR 26_ KGYRQ 31_ RLELS 36_ DIYQI 41_ PSVDS 46_ ADNLS 51_ EKLER 56_ EWDRE 61_ LASKK 66_ NPKLI 71_ NALRR 76_ CFFWR 81_ FMFYG 86_ IFLYL 91_ GEVTK 96_ AVQPL 101_ LLGRI 106_ IASYD 111_ PDNKE 116_ ERSIA 121_ IYLGI 126_ GLCLL 131_ FIVRT 136_ LLLHP 141_ AIFGL 146_ HHIGM 151_ QMRIA 156_ MFSLI 161_ YKKTL 166_ KLSSR 171_ VLDKI 176_ SIGQL 181_ VSLLS 186_ NNLNK 191_ FDEGL 196_ ALAHF 201_ VWIAP 206_ LQVAL 211_ LMGLI 216_ WELLQ 221_ ASAFC 226_ GLGFL 231_ IVLAL 236_ FQAGL 241_ GRMMM 246_ KYRDQ 251_ RAGKI 256_ SERLV 261_ ITSEM 266_ IENIQ 271_ SVKAY 276_ CWEEA 281_ MEKMI 286_ ENLRQ 291_ TELKL 296_ TRKAA 301_ YVRYF 306_ NSSAF 311_ FFSGF 316_ FVVFL 321_ SVLPY 326_ ALIKG 331_ IILRK 336_ IFTTI 341_ SFCIV 346_ LRMAV 351_ TRQFP 356_ WAVQT 361_ WYDSL 366_ GAINK 371_ IQDFL 376_ QKQEY 381_ KTLEY 386_ NLTTT 391_ EVVME 396_ NVTAF 401_ WEEGF 406_ GELFE 411_ KAKQN 416_ NNNRK 421_ TSNGD 426_ DSLFF 431_ SNFSL 436_ LGTPV 441_ LKDIN 446_ FKIER 451_ GQLLA 456_ VAGST 461_ GAGKT 466_ SLLMV 471_ IMGEL 476_ EPSEG 481_ KIKHS 486_ GRISF 491_ CSQFS 496_ WIMPG 501_ TIKEN 506_ IIFGV 511_ SYDEY 516_ RYRSV 521_ IKACQ 526_ LEEDI 531_ SKFAE 536_ KDNIV 541_ LGEGG 546_ ITLSG 551_ GQRAR 556_ ISLAR 561_ AVYKD 566_ ADLYL 571_ LDSPF 576_ GYLDV 581_ LTEKE 586_ IFESC 591_ VCKLM 596_ ANKTR 601_ ILVTS 606_ KMEHL 611_ KKADK 616_ ILILH 621_ EGSSY 626_ FYGTF 631_ SELQN 636_ LQPDF 641_ SSKLM 646_ GCDSF 651_ DQFSA 656_ ERRNS 661_ ILTET 666_ LHRFS 671_ LEGDA 676_ PVSWT 681_ ETKKQ 686_ SFKQT 691_ GEFGE 696_ KRKNS 701_ ILNPI 706_ NSIRK 711_ FSIVQ 716_ KTPLQ 721_ MNGIE 726_ EDSDE 731_ PLERR 736_ LSLVP 741_ DSEQG 746_ EAILP 751_ RISVI 756_ STGPT 761_ LQARR 766_ RQSVL 771_ NLMTH 776_ SVNQG 781_ QNIHR 786_ KTTAS 791_ TRKVS 796_ LAPQA 801_ NLTEL 806_ DIYSR 811_ RLSQE 816_ TGLEI 821_ SEEIN 826_ EEDLK 831_ ECFFD 836_ DMESI 841_ PAVTT 846_ WNTYL 851_ RYITV 856_ HKSLI 861_ FVLIW 866_ CLVIF 871_ LAEVA 876_ ASLVV 881_ LWLLG 886_ NTPLQ 891_ DKGNS 896_ THSRN 901_ NSYAV 906_ IITST 911_ SSYYV 916_ FYIYV 921_ GVADT 926_ LLAMG 931_ FFRGL 936_ PLVHT 941_ LITVS 946_ KILHH 951_ KMLHS 956_ VLQAP 961_ MSTLN 966_ TLKAG 971_ GILNR 976_ FSKDI 981_ AILDD 986_ LLPLT 991_ IFDFI 996_ QLLLI 1001_ VIGAI 1006_ AVVAV 1011_ LQPYI 1016_ FVATV 1021_ PVIVA 1026_ FIMLR 1031_ AYFLQ 1036_ TSQQL 1041_ KQLES 1046_ EGRSP 1051_ IFTHL 1056_ VTSLK 1061_ GLWTL 1066_ RAFGR 1071_ QPYFE 1076_ TLFHK 1081_ ALNLH 1086_ TANWF 1091_ LYLST 1096_ LRWFQ 1101_ MRIEM 1106_ IFVIF 1111_ FIAVT 1116_ FISIL 1121_ TTGEG 1126_ EGRVG 1131_ IILTL 1136_ AMNIM 1141_ STLQW 1146_ AVNSS 1151_ IDVDS 1156_ LMRSV 1161_ SRVFK 1166_ FIDMP 1171_ TEGKP 1176_ TKSTK 1181_ PYKNG 1186_ QLSKV 1191_ MIIEN 1196_ SHVKK 1201_ DDIWP 1206_ SGGQM 1211_ TVKDL 1216_ TAKYT 1221_ EGGNA 1226_ ILENI 1231_ SFSIS 1236_ PGQRV 1241_ GLLGR 1246_ TGSGK 1251_ STLLS 1256_ AFLRL 1261_ LNTEG 1266_ EIQID 1271_ GVSWD 1276_ SITLQ 1281_ QWRKA 1286_ FGVIP 1291_ QKVFI 1296_ FSGTF 1301_ RKNLD 1306_ PYEQW 1311_ SDQEI 1316_ WKVAD 1321_ EVGLR 1326_ SVIEQ 1331_ FPGKL 1336_ DFVLV 1341_ DGGCV 1346_ LSHGH 1351_ KQLMC 1356_ LARSV 1361_ LSKAK 1366_ ILLLD 1371_ EPSAH 1376_ LDPVT 1381_ YQIIR 1386_ RTLKQ 1391_ AFADC 1396_ TVILC 1401_ EHRIE 1406_ AMLEC 1411_ QQFLV 1416_ IEENK 1421_ VRQYD 1426_ SIQKL 1431_ LNERS 1436_ LFRQA 1441_ ISPSD 1446_ RVKLF 1451_ PHRNS 1456_ SKCKS 1461_ KPQIA 1466_ ALKEE 1471_TEEEV
1: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851)