Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
1_MAWEA 6_ RREPG 11_ PRRAA 16_ VRETV 21_ MLLLC 26_ LGVPT 31_ GRPYN 36_ VDTES 41_ ALLYQ 46_ GPHNT 51_ LFGYS 56_ VVLHS 61_ HGANR 66_ WLLVG 71_ APTAN 76_ WLANA 81_ SVINP 86_ GAIYR 91_ CRIGK 96_ NPGQT 101_ CEQLQ 106_ LGSPN 111_ GEPCG 116_ KTCLE 121_ ERDNQ 126_ WLGVT 131_ LSRQP 136_ GENGS 141_ IVTCG 146_ HRWKN 151_ IFYIK 156_ NENKL 161_ PTGGC 166_ YGVPP 171_ DLRTE 176_ LSKRI 181_ APCYQ 186_ DYVKK 191_ FGENF 196_ ASCQA 201_ GISSF 206_ YTKDL 211_ IVMGA 216_ PGSSY 221_ WTGSL 226_ FVYNI 231_ TTNKY 236_ KAFLD 241_ KQNQV 246_ KFGSY 251_ LGYSV 256_ GAGHF 261_ RSQHT 266_ TEVVG 271_ GAPQH 276_ EQIGK 281_ AYIFS 286_ IDEKE 291_ LNILH 296_ EMKGK 301_ KLGSY 306_ FGASV 311_ CAVDL 316_ NADGF 321_ SDLLV 326_ GAPMQ 331_ STIRE 336_ EGRVF 341_ VYINS 346_ GSGAV 351_ MNAME 356_ TNLVG 361_ SDKYA 366_ ARFGE 371_ SIVNL 376_ GDIDN 381_ DGFED 386_ VAIGA 391_ PQEDD 396_ LQGAI 401_ YIYNG 406_ RADGI 411_ SSTFS 416_ QRIEG 421_ LQISK 426_ SLSMF 431_ GQSIS 436_ GQIDA 441_ DNNGY 446_ VDVAV 451_ GAFRS 456_ DSAVL 461_ LRTRP 466_ VVIVD 471_ ASLSH 476_ PESVN 481_ RTKFD 486_ CVENG 491_ WPSVC 496_ IDLTL 501_ CFSYK 506_ GKEVP 511_ GYIVL 516_ FYNMS 521_ LDVNR 526_ KAESP 531_ PRFYF 536_ SSNGT 541_ SDVIT 546_ GSIQV 551_ SSREA 556_ NCRTH 561_ QAFMR 566_ KDVRD 571_ ILTPI 576_ QIEAA 581_ YHLGP 586_ HVISK 591_ RSTEE 596_ FPPLQ 601_ PILQQ 606_ KKEKD 611_ IMKKT 616_ INFAR 621_ FCAHE 626_ NCSAD 631_ LQVSA 636_ KIGFL 641_ KPHEN 646_ KTYLA 651_ VGSMK 656_ TLMLN 661_ VSLFN 666_ AGDDA 671_ YETTL 676_ HVKLP 681_ VGLYF 686_ IKILE 691_ LEEKQ 696_ INCEV 701_ TDNSG 706_ VVQLD 711_ CSIGY 716_ IYVDH 721_ LSRID 726_ ISFLL 731_ DVSSL 736_ SRAEE 741_ DLSIT 746_ VHATC 751_ ENEEE 756_ MDNLK 761_ HSRVT 766_ VAIPL 771_ KYEVK 776_ LTVHG 781_ FVNPT 786_ SFVYG 791_ SNDEN 796_ EPETC 801_ MVEKM 806_ NLTFH 811_ VINTG 816_ NSMAP 821_ NVSVE 826_ IMVPN 831_ SFSPQ 836_ TDKLF 841_ NILDV 846_ QTTTG 851_ ECHFE 856_ NYQRV 861_ CALEQ 866_ QKSAM 871_ QTLKG 876_ IVRFL 881_ SKTDK 886_ RLLYC 891_ IKADP 896_ HCLNF 901_ LCNFG 906_ KMESG 911_ KEASV 916_ HIQLE 921_ GRPSI 926_ LEMDE 931_ TSALK 936_ FEIRA 941_ TGFPE 946_ PNPRV 951_ IELNK 956_ DENVA 961_ HVLLE 966_ GLHHQ 971_ RPKRY 976_ FTIVI 981_ ISSSL 986_ LLGLI 991_ VLLLI 996_ SYVMW 1001_ KAGFF 1006_ KRQYK 1011_ SILQE 1016_ ENRRD 1021_ SWSYI 1026_NSKSN
1: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072)