Complement component C6
1_MARRS 6_ VLYFI 11_ LLNAL 16_ INKGQ 21_ ACFCD 26_ HYAWT 31_ QWTSC 36_ SKTCN 41_ SGTQS 46_ RHRQI 51_ VVDKY 56_ YQENF 61_ CEQIC 66_ SKQET 71_ RECNW 76_ QRCPI 81_ NCLLG 86_ DFGPW 91_ SDCDP 96_ CIEKQ 101_ SKVRS 106_ VLRPS 111_ QFGGQ 116_ PCTAP 121_ LVAFQ 126_ PCIPS 131_ KLCKI 136_ EEADC 141_ KNKFR 146_ CDSGR 151_ CIARK 156_ LECNG 161_ ENDCG 166_ DNSDE 171_ RDCGR 176_ TKAVC 181_ TRKYN 186_ PIPSV 191_ QLMGN 196_ GFHFL 201_ AGEPR 206_ GEVLD 211_ NSFTG 216_ GICKT 221_ VKSSR 226_ TSNPY 231_ RVPAN 236_ LENVG 241_ FEVQT 246_ AEDDL 251_ KTDFY 256_ KDLTS 261_ LGHNE 266_ NQQGS 271_ FSSQG 276_ GSSFS 281_ VPIFY 286_ SSKRS 291_ ENINH 296_ NSAFK 301_ QAIQA 306_ SHKKD 311_ SSFIR 316_ IHKVM 321_ KVLNF 326_ TTKAK 331_ DLHLS 336_ DVFLK 341_ ALNHL 346_ PLEYN 351_ SALYS 356_ RIFDD 361_ FGTHY 366_ FTSGS 371_ LGGVY 376_ DLLYQ 381_ FSSEE 386_ LKNSG 391_ LTEEE 396_ AKHCV 401_ RIETK 406_ KRVLF 411_ AKKTK 416_ VEHRC 421_ TTNKL 426_ SEKHE 431_ GSFIQ 436_ GAEKS 441_ ISLIR 446_ GGRSE 451_ YGAAL 456_ AWEKG 461_ SSGLE 466_ EKTFS 471_ EWLES 476_ VKENP 481_ AVIDF 486_ ELAPI 491_ VDLVR 496_ NIPCA 501_ VTKRN 506_ NLRKA 511_ LQEYA 516_ AKFDP 521_ CQCAP 526_ CPNNG 531_ RPTLS 536_ GTECL 541_ CVCQS 546_ GTYGE 551_ NCEKQ 556_ SPDYK 561_ SNAVD 566_ GQWGC 571_ WSSWS 576_ TCDAT 581_ YKRSR 586_ TRECN 591_ NPAPQ 596_ RGGKR 601_ CEGEK 606_ RQEED 611_ CTFSI 616_ MENNG 621_ QPCIN 626_ DDEEM 631_ KEVDL 636_ PEIEA 641_ DSGCP 646_ QPVPP 651_ ENGFI 656_ RNEKQ 661_ LYLVG 666_ EDVEI 671_ SCLTG 676_ FETVG 681_ YQYFR 686_ CLPDG 691_ TWRQG 696_ DVECQ 701_ RTECI 706_ KPVVQ 711_ EVLTI 716_ TPFQR 721_ LYRIG 726_ ESIEL 731_ TCPKG 736_ FVVAG 741_ PSRYT 746_ CQGNS 751_ WTPPI 756_ SNSLT 761_ CEKDT 766_ LTKLK 771_ GHCQL 776_ GQKQS 781_ GSECI 786_ CMSPE 791_ EDCSH 796_ HSEDL 801_ CVFDT 806_ DSNDY 811_ FTSPA 816_ CKFLA 821_ EKCLN 826_ NQQLH 831_ FLHIG 836_ SCQDG 841_ RQLEW 846_ GLERT 851_ RLSSN 856_ STKKE 861_ SCGYD 866_ TCYDW 871_ EKCSA 876_ STSKC 881_ VCLLP 886_ PQCFK 891_ GGNQL 896_ YCVKM 901_ GSSTS 906_ EKTLN 911_ ICEVG 916_ TIRCA 921_ NRKME 926_ILHPG
1: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22267737, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291)