Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
1_MGHLS 6_ APLHR 11_ VRVPW 16_ QGLLL 21_ TASLL 26_ TFWNP 31_ PTTAQ 36_ LTTES 41_ MPFNV 46_ AEGKE 51_ VLLLV 56_ HNLPQ 61_ QLFGY 66_ SWYKG 71_ ERVDG 76_ NRQIV 81_ GYAIG 86_ TQQAT 91_ PGPAN 96_ SGRET 101_ IYPNA 106_ SLLIQ 111_ NVTQN 116_ DTGFY 121_ TLQVI 126_ KSDLV 131_ NEEAT 136_ GQFHV 141_ YPELP 146_ KPSIS 151_ SNNSN 156_ PVEDK 161_ DAVAF 166_ TCEPE 171_ TQDTT 176_ YLWWI 181_ NNQSL 186_ PVSPR 191_ LQLSN 196_ GNRTL 201_ TLLSV 206_ TRNDT 211_ GPYEC 216_ EIQNP 221_ VSANR 226_ SDPVT 231_ LNVTY 236_ GPDTP 241_ TISPS 246_ DTYYR 251_ PGANL 256_ SLSCY 261_ AASNP 266_ PAQYS 271_ WLING 276_ TFQQS 281_ TQELF 286_ IPNIT 291_ VNNSG 296_ SYTCH 301_ ANNSV 306_ TGCNR 311_ TTVKT 316_ IIVTE 321_ LSPVV 326_ AKPQI 331_ KASKT 336_ TVTGD 341_ KDSVN 346_ LTCST 351_ NDTGI 356_ SIRWF 361_ FKNQS 366_ LPSSE 371_ RMKLS 376_ QGNTT 381_ LSINP 386_ VKRED 391_ AGTYW 396_ CEVFN 401_ PISKN 406_ QSDPI 411_ MLNVN 416_ YNALP 421_ QENGL 426_ SPGAI 431_ AGIVI 436_ GVVAL 441_ VALIA 446_ VALAC 451_ FLHFG 456_ KTGRA 461_ SDQRD 466_ LTEHK 471_ PSVSN 476_ HTQDH 481_ SNDPP 486_ NKMNE 491_ VTYST 496_ LNFEA 501_ QQPTQ 506_ PTSAS 511_ PSLTA 516_ TEIIY 521_SEVKK
1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity)
2: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity)