Oncostatin-M (OSM)
1_MGVLL 6_ TQRTL 11_ LSLVL 16_ ALLFP 21_ SMASM 26_ AAIGS 31_ CSKEY 36_ RVLLG 41_ QLQKQ 46_ TDLMQ 51_ DTSRL 56_ LDPYI 61_ RIQGL 66_ DVPKL 71_ REHCR 76_ ERPGA 81_ FPSEE 86_ TLRGL 91_ GRRGF 96_ LQTLN 101_ ATLGC 106_ VLHRL 111_ ADLEQ 116_ RLPKA 121_ QDLER 126_ SGLNI 131_ EDLEK 136_ LQMAR 141_ PNILG 146_ LRNNI 151_ YCMAQ 156_ LLDNS 161_ DTAEP 166_ TKAGR 171_ GASQP 176_ PTPTP 181_ ASDAF 186_ QRKLE 191_ GCRFL 196_ HGYHR 201_ FMHSV 206_ GRVFS 211_ KWGES 216_ PNRSR 221_ RHSPH 226_ QALRK 231_ GVRRT 236_ RPSRK 241_ GKRLM 246_TRGQL
1: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity)