Gene name: PRG2

Uniprot entry:

P13727

Protein names:

Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]

Protein sequence:

1_MKLPL 6_ LLALL 11_ FGAVS 16_ ALHLR 21_ SETST 26_ FETPL 31_ GAKTL 36_ PEDEE 41_ TPEQE 46_ MEETP 51_ CRELE 56_ EEEEW 61_ GSGSE 66_ DASKK 71_ DGAVE 76_ SISVP 81_ DMVDK 86_ NLTCP 91_ EEEDT 96_ VKVVG 101_ IPGCQ 106_ TCRYL 111_ LVRSL 116_ QTFSQ 121_ AWFTC 126_ RRCYR 131_ GNLVS 136_ IHNFN 141_ INYRI 146_ QCSVS 151_ ALNQG 156_ QVWIG 161_ GRITG 166_ SGRCR 171_ RFQWV 176_ DGSRW 181_ NFAYW 186_ AAHQP 191_ WSRGG 196_ HCVAL 201_ CTRGG 206_ HWRRA 211_ HCLRR 216_LPFIC

Protein annotations

Protein functions:

1: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA