CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)
1_MGIQG 6_ GSVLF 11_ GLLLV 16_ LAVFC 21_ HSGHS 26_ LQCYN 31_ CPNPT 36_ ADCKT 41_ AVNCS 46_ SDFDA 51_ CLITK 56_ AGLQV 61_ YNKCW 66_ KFEHC 71_ NFNDV 76_ TTRLR 81_ ENELT 86_ YYCCK 91_ KDLCN 96_ FNEQL 101_ ENGGT 106_ SLSEK 111_ TVLLL 116_ VTPFL 121_AAAWS
1: Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260)
2: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes