Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]
1_MAATS 6_ LMSAL 11_ AARLL 16_ QPAHS 21_ CSLRL 26_ RPFHL 31_ AAVRN 36_ EAVVI 41_ SGRKL 46_ AQQIK 51_ QEVRQ 56_ EVEEW 61_ VASGN 66_ KRPHL 71_ SVILV 76_ GENPA 81_ SHSYV 86_ LNKTR 91_ AAAVV 96_ GINSE 101_ TIMKP 106_ ASISE 111_ EELLN 116_ LINKL 121_ NNDDN 126_ VDGLL 131_ VQLPL 136_ PEHID 141_ ERRIC 146_ NAVSP 151_ DKDVD 156_ GFHVI 161_ NVGRM 166_ CLDQY 171_ SMLPA 176_ TPWGV 181_ WEIIK 186_ RTGIP 191_ TLGKN 196_ VVVAG 201_ RSKNV 206_ GMPIA 211_ MLLHT 216_ DGAHE 221_ RPGGD 226_ ATVTI 231_ SHRYT 236_ PKEQL 241_ KKHTI 246_ LADIV 251_ ISAAG 256_ IPNLI 261_ TADMI 266_ KEGAA 271_ VIDVG 276_ INRVH 281_ DPVTA 286_ KPKLV 291_ GDVDF 296_ EGVRQ 301_ KAGYI 306_ TPVPG 311_ GVGPM 316_ TVAML 321_ MKNTI 326_ IAAKK 331_ VLRLE 336_ EREVL 341_KSKEL
1: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency