17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)
1_MARTV 6_ VLITG 11_ CSSGI 16_ GLHLA 21_ VRLAS 26_ DPSQS 31_ FKVYA 36_ TLRDL 41_ KTQGR 46_ LWEAA 51_ RALAC 56_ PPGSL 61_ ETLQL 66_ DVRDS 71_ KSVAA 76_ ARERV 81_ TEGRV 86_ DVLVC 91_ NAGLG 96_ LLGPL 101_ EALGE 106_ DAVAS 111_ VLDVN 116_ VVGTV 121_ RMLQA 126_ FLPDM 131_ KRRGS 136_ GRVLV 141_ TGSVG 146_ GLMGL 151_ PFNDV 156_ YCASK 161_ FALEG 166_ LCESL 171_ AVLLL 176_ PFGVH 181_ LSLIE 186_ CGPVH 191_ TAFME 196_ KVLGS 201_ PEEVL 206_ DRTDI 211_ HTFHR 216_ FYQYL 221_ AHSKQ 226_ VFREA 231_ AQNPE 236_ EVAEV 241_ FLTAL 246_ RAPKP 251_ TLRYF 256_ TTERF 261_ LPLLR 266_ MRLDD 271_ PSGSN 276_ YVTAM 281_ HREVF 286_ GDVPA 291_ KAEAG 296_ AEAGG 301_ GAGPG 306_ AEDEA 311_ GRGAV 316_ GDPEL 321_GDPPA
1: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH