Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)
1_MVWKW 6_ MPLLL 11_ LLVCV 16_ ATMCS 21_ AQDRT 26_ DLLNV 31_ CMDAK 36_ HHKTK 41_ PGPED 46_ KLHDQ 51_ CSPWK 56_ KNACC 61_ TASTS 66_ QELHK 71_ DTSRL 76_ YNFNW 81_ DHCGK 86_ MEPAC 91_ KRHFI 96_ QDTCL 101_ YECSP 106_ NLGPW 111_ IQQVN 116_ QSWRK 121_ ERFLD 126_ VPLCK 131_ EDCQR 136_ WWEDC 141_ HTSHT 146_ CKSNW 151_ HRGWD 156_ WTSGV 161_ NKCPA 166_ GALCR 171_ TFESY 176_ FPTPA 181_ ALCEG 186_ LWSHS 191_ YKVSN 196_ YSRGS 201_ GRCIQ 206_ MWFDS 211_ AQGNP 216_ NEEVA 221_ RFYAA 226_ AMHVN 231_ AGEML 236_ HGTGG 241_ LLLSL 246_ALMLQ
1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release