Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
1_MAARL 6_ LLLGI 11_ LLLLL 16_ PLPVP 21_ APCHT 26_ AARSE 31_ CKRSH 36_ KFVPG 41_ AWLAG 46_ EGVDV 51_ TSLRR 56_ SGSFP 61_ VDTQR 66_ FLRPD 71_ GTCTL 76_ CENAL 81_ QEGTL 86_ QRLPL 91_ ALTNW 96_ RAQGS 101_ GCQRH 106_ VTRAK 111_ VSSTE 116_ AVARD 121_ AARSI 126_ RNDWK 131_ VGLDV 136_ TPKPT 141_ SNVHV 146_ SVAGS 151_ HSQAA 156_ NFAAQ 161_ KTHQD 166_ QYSFS 171_ TDTVE 176_ CRFYS 181_ FHVVH 186_ TPPLH 191_ PDFKR 196_ ALGDL 201_ PHHFN 206_ ASTQP 211_ AYLRL 216_ ISNYG 221_ THFIR 226_ AVELG 231_ GRISA 236_ LTALR 241_ TCELA 246_ LEGLT 251_ DNEVE 256_ DCLTV 261_ EAQVN 266_ IGIHG 271_ SISAE 276_ AKACE 281_ EKKKK 286_ HKMTA 291_ SFHQT 296_ YRERH 301_ SEVVG 306_ GHHTS 311_ INDLL 316_ FGIQA 321_ GPEQY 326_ SAWVN 331_ SLPGS 336_ PGLVD 341_ YTLEP 346_ LHVLL 351_ DSQDP 356_ RREAL 361_ RRALS 366_ QYLTD 371_ RARWR 376_ DCSRP 381_ CPPGR 386_ QKSPR 391_ DPCQC 396_ VCHGS 401_ AVTTQ 406_ DCCPR 411_ QRGLA 416_ QLEVT 421_ FIQAW 426_ GLWGD 431_ WFTAT 436_ DAYVK 441_ LFFGG 446_ QELRT 451_ STVWD 456_ NNNPI 461_ WSVRL 466_ DFGDV 471_ LLATG 476_ GPLRL 481_ QVWDQ 486_ DSGRD 491_ DDLLG 496_ TCDQA 501_ PKSGS 506_ HEVRC 511_ NLNHG 516_ HLKFR 521_ YHARC 526_ LPHLG 531_ GGTCL 536_ DYVPQ 541_ MLLGE 546_PPGNR
1: Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:20889983, PubMed:21037563, PubMed:24558045, PubMed:9058810, PubMed:9164947). Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease (PubMed:9058810). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:20889983, PubMed:21037563). Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes (PubMed:20038786, PubMed:20225066, PubMed:24558045, PubMed:32299851). Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently (PubMed:24558045). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (By similarity)