Interferon regulatory factor 2 (IRF-2)
1_MPVER 6_ MRMRP 11_ WLEEQ 16_ INSNT 21_ IPGLK 26_ WLNKE 31_ KKIFQ 36_ IPWMH 41_ AARHG 46_ WDVEK 51_ DAPLF 56_ RNWAI 61_ HTGKH 66_ QPGVD 71_ KPDPK 76_ TWKAN 81_ FRCAM 86_ NSLPD 91_ IEEVK 96_ DKSIK 101_ KGNNA 106_ FRVYR 111_ MLPLS 116_ ERPSK 121_ KGKKP 126_ KTEKE 131_ DKVKH 136_ IKQEP 141_ VESSL 146_ GLSNG 151_ VSDLS 156_ PEYAV 161_ LTSTI 166_ KNEVD 171_ STVNI 176_ IVVGQ 181_ SHLDS 186_ NIENQ 191_ EIVTN 196_ PPDIC 201_ QVVEV 206_ TTESD 211_ EQPVS 216_ MSELY 221_ PLQIS 226_ PVSSY 231_ AESET 236_ TDSVP 241_ SDEES 246_ AEGRP 251_ HWRKR 256_ NIEGK 261_ QYLSN 266_ MGTRG 271_ SYLLP 276_ GMASF 281_ VTSNK 286_ PDLQV 291_ TIKEE 296_ SNPVP 301_ YNSSW 306_ PPFQD 311_ LPLSS 316_ SMTPA 321_ SSSSR 326_ PDRET 331_ RASVI 336_ KKTSD 341_ITQAR
1: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation