Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)
1_MPLSR 6_ WLRSV 11_ GVFLL 16_ PAPYW 21_ APRER 26_ WLGSL 31_ RRPSL 36_ VHGYP 41_ VLAWH 46_ SARCW 51_ CQAWT 56_ EEPRA 61_ LCSSL 66_ RMNGD 71_ QNSDV 76_ YAQEK 81_ QDFVQ 86_ HFSQI 91_ VRVLT 96_ EDEMG 101_ HPEIG 106_ DAIAR 111_ LKEVL 116_ EYNAI 121_ GGKYN 126_ RGLTV 131_ VVAFR 136_ ELVEP 141_ RKQDA 146_ DSLQR 151_ AWTVG 156_ WCVEL 161_ LQAFF 166_ LVADD 171_ IMDSS 176_ LTRRG 181_ QICWY 186_ QKPGV 191_ GLDAI 196_ NDANL 201_ LEACI 206_ YRLLK 211_ LYCRE 216_ QPYYL 221_ NLIEL 226_ FLQSS 231_ YQTEI 236_ GQTLD 241_ LLTAP 246_ QGNVD 251_ LVRFT 256_ EKRYK 261_ SIVKY 266_ KTAFY 271_ SFYLP 276_ IAAAM 281_ YMAGI 286_ DGEKE 291_ HANAK 296_ KILLE 301_ MGEFF 306_ QIQDD 311_ YLDLF 316_ GDPSV 321_ TGKIG 326_ TDIQD 331_ NKCSW 336_ LVVQC 341_ LQRAT 346_ PEQYQ 351_ ILKEN 356_ YGQKE 361_ AEKVA 366_ RVKAL 371_ YEELD 376_ LPAVF 381_ LQYEE 386_ DSYSH 391_ IMALI 396_ EQYAA 401_ PLPPA 406_ VFLGL 411_ARKIY
1: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate