Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27)
1_MASGS 6_ VAECL 11_ QQETT 16_ CPVCL 21_ QYFAE 26_ PMMLD 31_ CGHNI 36_ CCACL 41_ ARCWG 46_ TAETN 51_ VSCPQ 56_ CRETF 61_ PQRHM 66_ RPNRH 71_ LANVT 76_ QLVKQ 81_ LRTER 86_ PSGPG 91_ GEMGV 96_ CEKHR 101_ EPLKL 106_ YCEED 111_ QMPIC 116_ VVCDR 121_ SREHR 126_ GHSVL 131_ PLEEA 136_ VEGFK 141_ EQIQN 146_ QLDHL 151_ KRVKD 156_ LKKRR 161_ RAQGE 166_ QARAE 171_ LLSLT 176_ QMERE 181_ KIVWE 186_ FEQLY 191_ HSLKE 196_ HEYRL 201_ LARLE 206_ ELDLA 211_ IYNSI 216_ NGAIT 221_ QFSCN 226_ ISHLS 231_ SLIAQ 236_ LEEKQ 241_ QQPTR 246_ ELLQD 251_ IGDTL 256_ SRAER 261_ IRIPE 266_ PWITP 271_ PDLQE 276_ KIHIF 281_ AQKCL 286_ FLTES 291_ LKQFT 296_ EKMQS 301_ DMEKI 306_ QELRE 311_ AQLYS 316_ VDVTL 321_ DPDTA 326_ YPSLI 331_ LSDNL 336_ RQVRY 341_ SYLQQ 346_ DLPDN 351_ PERFN 356_ LFPCV 361_ LGSPC 366_ FIAGR 371_ HYWEV 376_ EVGDK 381_ AKWTI 386_ GVCED 391_ SVCRK 396_ GGVTS 401_ APQNG 406_ FWAVS 411_ LWYGK 416_ EYWAL 421_ TSPMT 426_ ALPLR 431_ TPLQR 436_ VGIFL 441_ DYDAG 446_ EVSFY 451_ NVTER 456_ CHTFT 461_ FSHAT 466_ FCGPV 471_ RPYFS 476_ LSYSG 481_ GKSAA 486_ PLIIC 491_ PMSGI 496_ DGFSG 501_ HVGNH 506_GHSME
1: E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (PubMed:26358190, PubMed:29688809). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (PubMed:22829933). Alternatively, facilitates mitophagy via stabilization of active TBK1 (PubMed:36111389). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (PubMed:35670107). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (PubMed:35670107)
2: (Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection