Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
1_MGDTF 6_ IRHIA 11_ LLGFE 16_ KRFVP 21_ SQHYV 26_ YMFLV 31_ KWQDL 36_ SEKVV 41_ YRRFT 46_ EIYEF 51_ HKTLK 56_ EMFPI 61_ EAGAI 66_ NPENR 71_ IIPHL 76_ PAPKW 81_ FDGQR 86_ AAENR 91_ QGTLT 96_ EYCST 101_ LMSLP 106_ TKISR 111_ CPHLL 116_ DFFKV 121_ RPDDL 126_ KLPTD 131_ NQTKK 136_ PETYL 141_ MPKDG 146_ KSTAT 151_ DITGP 156_ IILQT 161_ YRAIA 166_ NYEKT 171_ SGSEM 176_ ALSTG 181_ DVVEV 186_ VEKSE 191_ SGWWF 196_ CQMKA 201_ KRGWI 206_ PASFL 211_ EPLDS 216_ PDETE 221_ DPEPN 226_ YAGEP 231_ YVAIK 236_ AYTAV 241_ EGDEV 246_ SLLEG 251_ EAVEV 256_ IHKLL 261_ DGWWV 266_ IRKDD 271_ VTGYF 276_ PSMYL 281_ QKSGQ 286_ DVSQA 291_ QRQIK 296_ RGAPP 301_ RRSSI 306_ RNAHS 311_ IHQRS 316_ RKRLS 321_ QDAYR 326_ RNSVR 331_ FLQQR 336_ RRQAR 341_ PGPQS 346_ PGSPL 351_ EEERQ 356_ TQRSK 361_ PQPAV 366_ PPRPS 371_ ADLIL 376_ NRCSE 381_STKRK
1: Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500)