Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)
1_MRALW 6_ VLGLC 11_ CVLLT 16_ FGSVR 21_ ADDEV 26_ DVDGT 31_ VEEDL 36_ GKSRE 41_ GSRTD 46_ DEVVQ 51_ REEEA 56_ IQLDG 61_ LNASQ 66_ IRELR 71_ EKSEK 76_ FAFQA 81_ EVNRM 86_ MKLII 91_ NSLYK 96_ NKEIF 101_ LRELI 106_ SNASD 111_ ALDKI 116_ RLISL 121_ TDENA 126_ LSGNE 131_ ELTVK 136_ IKCDK 141_ EKNLL 146_ HVTDT 151_ GVGMT 156_ REELV 161_ KNLGT 166_ IAKSG 171_ TSEFL 176_ NKMTE 181_ AQEDG 186_ QSTSE 191_ LIGQF 196_ GVGFY 201_ SAFLV 206_ ADKVI 211_ VTSKH 216_ NNDTQ 221_ HIWES 226_ DSNEF 231_ SVIAD 236_ PRGNT 241_ LGRGT 246_ TITLV 251_ LKEEA 256_ SDYLE 261_ LDTIK 266_ NLVKK 271_ YSQFI 276_ NFPIY 281_ VWSSK 286_ TETVE 291_ EPMEE 296_ EEAAK 301_ EEKEE 306_ SDDEA 311_ AVEEE 316_ EEEKK 321_ PKTKK 326_ VEKTV 331_ WDWEL 336_ MNDIK 341_ PIWQR 346_ PSKEV 351_ EEDEY 356_ KAFYK 361_ SFSKE 366_ SDDPM 371_ AYIHF 376_ TAEGE 381_ VTFKS 386_ ILFVP 391_ TSAPR 396_ GLFDE 401_ YGSKK 406_ SDYIK 411_ LYVRR 416_ VFITD 421_ DFHDM 426_ MPKYL 431_ NFVKG 436_ VVDSD 441_ DLPLN 446_ VSRET 451_ LQQHK 456_ LLKVI 461_ RKKLV 466_ RKTLD 471_ MIKKI 476_ ADDKY 481_ NDTFW 486_ KEFGT 491_ NIKLG 496_ VIEDH 501_ SNRTR 506_ LAKLL 511_ RFQSS 516_ HHPTD 521_ ITSLD 526_ QYVER 531_ MKEKQ 536_ DKIYF 541_ MAGSS 546_ RKEAE 551_ SSPFV 556_ ERLLK 561_ KGYEV 566_ IYLTE 571_ PVDEY 576_ CIQAL 581_ PEFDG 586_ KRFQN 591_ VAKEG 596_ VKFDE 601_ SEKTK 606_ ESREA 611_ VEKEF 616_ EPLLN 621_ WMKDK 626_ ALKDK 631_ IEKAV 636_ VSQRL 641_ TESPC 646_ ALVAS 651_ QYGWS 656_ GNMER 661_ IMKAQ 666_ AYQTG 671_ KDIST 676_ NYYAS 681_ QKKTF 686_ EINPR 691_ HPLIR 696_ DMLRR 701_ IKEDE 706_ DDKTV 711_ LDLAV 716_ VLFET 721_ ATLRS 726_ GYLLP 731_ DTKAY 736_ GDRIE 741_ RMLRL 746_ SLNID 751_ PDAKV 756_ EEEPE 761_ EEPEE 766_ TAEDT 771_ TEDTE 776_ QDEDE 781_ EMDVG 786_ TDEEE 791_ ETAKE 796_STAEK
1: ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059)