Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
1_MPSGF 6_ QQIGS 11_ EDGEP 16_ PQQRV 21_ TGTLV 26_ LAVFS 31_ AVLGS 36_ LQFGY 41_ NIGVI 46_ NAPQK 51_ VIEQS 56_ YNETW 61_ LGRQG 66_ PEGPS 71_ SIPPG 76_ TLTTL 81_ WALSV 86_ AIFSV 91_ GGMIS 96_ SFLIG 101_ IISQW 106_ LGRKR 111_ AMLVN 116_ NVLAV 121_ LGGSL 126_ MGLAN 131_ AAASY 136_ EMLIL 141_ GRFLI 146_ GAYSG 151_ LTSGL 156_ VPMYV 161_ GEIAP 166_ THLRG 171_ ALGTL 176_ NQLAI 181_ VIGIL 186_ IAQVL 191_ GLESL 196_ LGTAS 201_ LWPLL 206_ LGLTV 211_ LPALL 216_ QLVLL 221_ PFCPE 226_ SPRYL 231_ YIIQN 236_ LEGPA 241_ RKSLK 246_ RLTGW 251_ ADVSG 256_ VLAEL 261_ KDEKR 266_ KLERE 271_ RPLSL 276_ LQLLG 281_ SRTHR 286_ QPLII 291_ AVVLQ 296_ LSQQL 301_ SGINA 306_ VFYYS 311_ TSIFE 316_ TAGVG 321_ QPAYA 326_ TIGAG 331_ VVNTV 336_ FTLVS 341_ VLLVE 346_ RAGRR 351_ TLHLL 356_ GLAGM 361_ CGCAI 366_ LMTVA 371_ LLLLE 376_ RVPAM 381_ SYVSI 386_ VAIFG 391_ FVAFF 396_ EIGPG 401_ PIPWF 406_ IVAEL 411_ FSQGP 416_ RPAAM 421_ AVAGF 426_ SNWTS 431_ NFIIG 436_ MGFQY 441_ VAEAM 446_ GPYVF 451_ LLFAV 456_ LLLGF 461_ FIFTF 466_ LRVPE 471_ TRGRT 476_ FDQIS 481_ AAFHR 486_ TPSLL 491_ EQEVK 496_ PSTEL 501_EYLGP
1: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell