Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB)
1_MLLAV 6_ LYCLL 11_ WSFQT 16_ SAGHF 21_ PRACV 26_ SSKNL 31_ MEKEC 36_ CPPWS 41_ GDRSP 46_ CGQLS 51_ GRGSC 56_ QNILL 61_ SNAPL 66_ GPQFP 71_ FTGVD 76_ DRESW 81_ PSVFY 86_ NRTCQ 91_ CSGNF 96_ MGFNC 101_ GNCKF 106_ GFWGP 111_ NCTER 116_ RLLVR 121_ RNIFD 126_ LSAPE 131_ KDKFF 136_ AYLTL 141_ AKHTI 146_ SSDYV 151_ IPIGT 156_ YGQMK 161_ NGSTP 166_ MFNDI 171_ NIYDL 176_ FVWMH 181_ YYVSM 186_ DALLG 191_ GSEIW 196_ RDIDF 201_ AHEAP 206_ AFLPW 211_ HRLFL 216_ LRWEQ 221_ EIQKL 226_ TGDEN 231_ FTIPY 236_ WDWRD 241_ AEKCD 246_ ICTDE 251_ YMGGQ 256_ HPTNP 261_ NLLSP 266_ ASFFS 271_ SWQIV 276_ CSRLE 281_ EYNSH 286_ QSLCN 291_ GTPEG 296_ PLRRN 301_ PGNHD 306_ KSRTP 311_ RLPSS 316_ ADVEF 321_ CLSLT 326_ QYESG 331_ SMDKA 336_ ANFSF 341_ RNTLE 346_ GFASP 351_ LTGIA 356_ DASQS 361_ SMHNA 366_ LHIYM 371_ NGTMS 376_ QVQGS 381_ ANDPI 386_ FLLHH 391_ AFVDS 396_ IFEQW 401_ LRRHR 406_ PLQEV 411_ YPEAN 416_ APIGH 421_ NRESY 426_ MVPFI 431_ PLYRN 436_ GDFFI 441_ SSKDL 446_ GYDYS 451_ YLQDS 456_ DPDSF 461_ QDYIK 466_ SYLEQ 471_ ASRIW 476_ SWLLG 481_ AAMVG 486_ AVLTA 491_ LLAGL 496_ VSLLC 501_ RHKRK 506_ QLPEE 511_ KQPLL 516_ MEKED 521_YHSLY
1: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582)