Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
1_MRYRL 6_ AWLLH 11_ PALPS 16_ TFRSV 21_ LGARL 26_ PPPER 31_ LCGFQ 36_ KKTYS 41_ KMNNP 46_ AIKRI 51_ GNHIT 56_ KSPED 61_ KREYR 66_ GLELA 71_ NGIKV 76_ LLISD 81_ PTTDK 86_ SSAAL 91_ DVHIG 96_ SLSDP 101_ PNIAG 106_ LSHFC 111_ EHMLF 116_ LGTKK 121_ YPKEN 126_ EYSQF 131_ LSEHA 136_ GSSNA 141_ FTSGE 146_ HTNYY 151_ FDVSH 156_ EHLEG 161_ ALDRF 166_ AQFFL 171_ CPLFD 176_ ESCKD 181_ REVNA 186_ VDSEH 191_ EKNVM 196_ NDAWR 201_ LFQLE 206_ KATGN 211_ PKHPF 216_ SKFGT 221_ GNKYT 226_ LETRP 231_ NQEGI 236_ DVRQE 241_ LLKFH 246_ SAYYS 251_ SNLMA 256_ VCVLG 261_ RESLD 266_ DLTNL 271_ VVKLF 276_ SEVEN 281_ KNVPL 286_ PEFPE 291_ HPFQE 296_ EHLKQ 301_ LYKIV 306_ PIKDI 311_ RNLYV 316_ TFPIP 321_ DLQKY 326_ YKSNP 331_ GHYLG 336_ HLIGH 341_ EGPGS 346_ LLSEL 351_ KSKGW 356_ VNTLV 361_ GGQKE 366_ GARGF 371_ MFFII 376_ NVDLT 381_ EEGLL 386_ HVEDI 391_ ILHMF 396_ QYIQK 401_ LRAEG 406_ PQEWV 411_ FQECK 416_ DLNAV 421_ AFRFK 426_ DKERP 431_ RGYTS 436_ KIAGI 441_ LHYYP 446_ LEEVL 451_ TAEYL 456_ LEEFR 461_ PDLIE 466_ MVLDK 471_ LRPEN 476_ VRVAI 481_ VSKSF 486_ EGKTD 491_ RTEEW 496_ YGTQY 501_ KQEAI 506_ PDEVI 511_ KKWQN 516_ ADLNG 521_ KFKLP 526_ TKNEF 531_ IPTNF 536_ EILPL 541_ EKEAT 546_ PYPAL 551_ IKDTA 556_ MSKLW 561_ FKQDD 566_ KFFLP 571_ KACLN 576_ FEFFS 581_ PFAYV 586_ DPLHC 591_ NMAYL 596_ YLELL 601_ KDSLN 606_ EYAYA 611_ AELAG 616_ LSYDL 621_ QNTIY 626_ GMYLS 631_ VKGYN 636_ DKQPI 641_ LLKKI 646_ IEKMA 651_ TFEID 656_ EKRFE 661_ IIKEA 666_ YMRSL 671_ NNFRA 676_ EQPHQ 681_ HAMYY 686_ LRLLM 691_ TEVAW 696_ TKDEL 701_ KEALD 706_ DVTLP 711_ RLKAF 716_ IPQLL 721_ SRLHI 726_ EALLH 731_ GNITK 736_ QAALG 741_ IMQMV 746_ EDTLI 751_ EHAHT 756_ KPLLP 761_ SQLVR 766_ YREVQ 771_ LPDRG 776_ WFVYQ 781_ QRNEV 786_ HNNCG 791_ IEIYY 796_ QTDMQ 801_ STSEN 806_ MFLEL 811_ FCQII 816_ SEPCF 821_ NTLRT 826_ KEQLG 831_ YIVFS 836_ GPRRA 841_ NGIQG 846_ LRFII 851_ QSEKP 856_ PHYLE 861_ SRVEA 866_ FLITM 871_ EKSIE 876_ DMTEE 881_ AFQKH 886_ IQALA 891_ IRRLD 896_ KPKKL 901_ SAECA 906_ KYWGE 911_ IISQQ 916_ YNFDR 921_ DNTEV 926_ AYLKT 931_ LTKED 936_ IIKFY 941_ KEMLA 946_ VDAPR 951_ RHKVS 956_ VHVLA 961_ REMDS 966_ CPVVG 971_ EFPCQ 976_ NDINL 981_ SQAPA 986_ LPQPE 991_ VIQNM 996_ TEFKR 1001_ GLPLF 1006_ PLVKP 1011_HINFM
1: Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:10684867, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446, PubMed:21098034, PubMed:2293021, PubMed:23922390, PubMed:24847884, PubMed:26394692, PubMed:26968463, PubMed:29596046). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable) (PubMed:26394692, PubMed:9830016). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I
2: (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV)