Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
1_MKVLL 6_ RLICF 11_ IALLI 16_ SSLEA 21_ DKCKE 26_ REEKI 31_ ILVSS 36_ ANEID 41_ VRPCP 46_ LNPNE 51_ HKGTI 56_ TWYKD 61_ DSKTP 66_ VSTEQ 71_ ASRIH 76_ QHKEK 81_ LWFVP 86_ AKVED 91_ SGHYY 96_ CVVRN 101_ SSYCL 106_ RIKIS 111_ AKFVE 116_ NEPNL 121_ CYNAQ 126_ AIFKQ 131_ KLPVA 136_ GDGGL 141_ VCPYM 146_ EFFKN 151_ ENNEL 156_ PKLQW 161_ YKDCK 166_ PLLLD 171_ NIHFS 176_ GVKDR 181_ LIVMN 186_ VAEKH 191_ RGNYT 196_ CHASY 201_ TYLGK 206_ QYPIT 211_ RVIEF 216_ ITLEE 221_ NKPTR 226_ PVIVS 231_ PANET 236_ MEVDL 241_ GSQIQ 246_ LICNV 251_ TGQLS 256_ DIAYW 261_ KWNGS 266_ VIDED 271_ DPVLG 276_ EDYYS 281_ VENPA 286_ NKRRS 291_ TLITV 296_ LNISE 301_ IESRF 306_ YKHPF 311_ TCFAK 316_ NTHGI 321_ DAAYI 326_ QLIYP 331_ VTNFQ 336_ KHMIG 341_ ICVTL 346_ TVIIV 351_ CSVFI 356_ YKIFK 361_ IDIVL 366_ WYRDS 371_ CYDFL 376_ PIKAS 381_ DGKTY 386_ DAYIL 391_ YPKTV 396_ GEGST 401_ SDCDI 406_ FVFKV 411_ LPEVL 416_ EKQCG 421_ YKLFI 426_ YGRDD 431_ YVGED 436_ IVEVI 441_ NENVK 446_ KSRRL 451_ IIILV 456_ RETSG 461_ FSWLG 466_ GSSEE 471_ QIAMY 476_ NALVQ 481_ DGIKV 486_ VLLEL 491_ EKIQD 496_ YEKMP 501_ ESIKF 506_ IKQKH 511_ GAIRW 516_ SGDFT 521_ QGPQS 526_ AKTRF 531_ WKNVR 536_ YHMPV 541_ QRRSP 546_ SSKHQ 551_ LLSPA 556_ TKEKL 561_QREAH
1: Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850)