Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
1_MSRRL 6_ LPRAE 11_ KRRRR 16_ LEQRQ 21_ QPDEQ 26_ RRRSG 31_ AMVKM 36_ AAAGG 41_ GGGGG 46_ RYYGG 51_ GSEGG 56_ RAPKR 61_ LKTDN 66_ AGDQH 71_ GGGGG 76_ GGGGA 81_ GAAGG 86_ GGGGE 91_ NYDDP 96_ HKTPA 101_ SPVVH 106_ IRGLI 111_ DGVVE 116_ ADLVE 121_ ALQEF 126_ GPISY 131_ VVVMP 136_ KKRQA 141_ LVEFE 146_ DVLGA 151_ CNAVN 156_ YAADN 161_ QIYIA 166_ GHPAF 171_ VNYST 176_ SQKIS 181_ RPGDS 186_ DDSRS 191_ VNSVL 196_ LFTIL 201_ NPIYS 206_ ITTDV 211_ LYTIC 216_ NPCGP 221_ VQRIV 226_ IFRKN 231_ GVQAM 236_ VEFDS 241_ VQSAQ 246_ RAKAS 251_ LNGAD 256_ IYSGC 261_ CTLKI 266_ EYAKP 271_ TRLNV 276_ FKNDQ 281_ DTWDY 286_ TNPNL 291_ SGQGD 296_ PGSNP 301_ NKRQR 306_ QPPLL 311_ GDHPA 316_ EYGGP 321_ HGGYH 326_ SHYHD 331_ EGYGP 336_ PPPHY 341_ EGRRM 346_ GPPVG 351_ GHRRG 356_ PSRYG 361_ PQYGH 366_ PPPPP 371_ PPPEY 376_ GPHAD 381_ SPVLM 386_ VYGLD 391_ QSKMN 396_ CDRVF 401_ NVFCL 406_ YGNVE 411_ KVKFM 416_ KSKPG 421_ AAMVE 426_ MADGY 431_ AVDRA 436_ ITHLN 441_ NNFMF 446_ GQKLN 451_ VCVSK 456_ QPAIM 461_ PGQSY 466_ GLEDG 471_ SCSYK 476_ DFSES 481_ RNNRF 486_ STPEQ 491_ AAKNR 496_ IQHPS 501_ NVLHF 506_ FNAPL 511_ EVTEE 516_ NFFEI 521_ CDELG 526_ VKRPS 531_ SVKVF 536_ SGKSE 541_ RSSSG 546_ LLEWE 551_ SKSDA 556_ LETLG 561_ FLNHY 566_ QMKNP 571_ NGPYP 576_ YTLKL 581_CFSTA
1: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8