Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1)
1_MRKSP 6_ GLSDC 11_ LWAWI 16_ LLLST 21_ LTGRS 26_ YGQPS 31_ LQDEL 36_ KDNTT 41_ VFTRI 46_ LDRLL 51_ DGYDN 56_ RLRPG 61_ LGERV 66_ TEVKT 71_ DIFVT 76_ SFGPV 81_ SDHDM 86_ EYTID 91_ VFFRQ 96_ SWKDE 101_ RLKFK 106_ GPMTV 111_ LRLNN 116_ LMASK 121_ IWTPD 126_ TFFHN 131_ GKKSV 136_ AHNMT 141_ MPNKL 146_ LRITE 151_ DGTLL 156_ YTMRL 161_ TVRAE 166_ CPMHL 171_ EDFPM 176_ DAHAC 181_ PLKFG 186_ SYAYT 191_ RAEVV 196_ YEWTR 201_ EPARS 206_ VVVAE 211_ DGSRL 216_ NQYDL 221_ LGQTV 226_ DSGIV 231_ QSSTG 236_ EYVVM 241_ TTHFH 246_ LKRKI 251_ GYFVI 256_ QTYLP 261_ CIMTV 266_ ILSQV 271_ SFWLN 276_ RESVP 281_ ARTVF 286_ GVTTV 291_ LTMTT 296_ LSISA 301_ RNSLP 306_ KVAYA 311_ TAMDW 316_ FIAVC 321_ YAFVF 326_ SALIE 331_ FATVN 336_ YFTKR 341_ GYAWD 346_ GKSVV 351_ PEKPK 356_ KVKDP 361_ LIKKN 366_ NTYAP 371_ TATSY 376_ TPNLA 381_ RGDPG 386_ LATIA 391_ KSATI 396_ EPKEV 401_ KPETK 406_ PPEPK 411_ KTFNS 416_ VSKID 421_ RLSRI 426_ AFPLL 431_ FGIFN 436_ LVYWA 441_ TYLNR 446_ EPQLK 451_APTPH
1: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, PubMed:30602789). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:23909897, PubMed:29950725, PubMed:30602789). Alpha-1/GABRA1-containing GABAARs are largely synaptic (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity)