Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)
1_MAHAM 6_ ENSWT 11_ ISKEY 16_ HIDEE 21_ VGFAL 26_ PNPQE 31_ NLPDF 36_ YNDWM 41_ FIAKH 46_ LPDLI 51_ ESGQL 56_ RERVE 61_ KLNML 66_ SIDHL 71_ TDHKS 76_ QRLAR 81_ LVLGC 86_ ITMAY 91_ VWGKG 96_ HGDVR 101_ KVLPR 106_ NIAVP 111_ YCQLS 116_ KKLEL 121_ PPILV 126_ YADCV 131_ LANWK 136_ KKDPN 141_ KPLTY 146_ ENMDV 151_ LFSFR 156_ DGDCS 161_ KGFFL 166_ VSLLV 171_ EIAAA 176_ SAIKV 181_ IPTVF 186_ KAMQM 191_ QERDT 196_ LLKAL 201_ LEIAS 206_ CLEKA 211_ LQVFH 216_ QIHDH 221_ VNPKA 226_ FFSVL 231_ RIYLS 236_ GWKGN 241_ PQLSD 246_ GLVYE 251_ GFWED 256_ PKEFA 261_ GGSAG 266_ QSSVF 271_ QCFDV 276_ LLGIQ 281_ QTAGG 286_ GHAAQ 291_ FLQDM 296_ RRYMP 301_ PAHRN 306_ FLCSL 311_ ESNPS 316_ VREFV 321_ LSKGD 326_ AGLRE 331_ AYDAC 336_ VKALV 341_ SLRSY 346_ HLQIV 351_ TKYIL 356_ IPASQ 361_ QPKEN 366_ KTSED 371_ PSKLE 376_ AKGTG 381_ GTDLM 386_ NFLKT 391_ VRSTT 396_EKSLL
1: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:14502282, PubMed:23103127, PubMed:25157255, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885)