Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
1_MEVMN 6_ LMEQP 11_ IKVTE 16_ WQQTY 21_ TYDSG 26_ IHSGA 31_ NTCVP 36_ SVSSK 41_ GIMEE 46_ DEACG 51_ RQYTL 56_ KKTTT 61_ YTQGV 66_ PPSQG 71_ DLEYQ 76_ MSTTA 81_ RAKRV 86_ REAMC 91_ PGVSG 96_ EDSSL 101_ LLATQ 106_ VEGQA 111_ TNLQR 116_ LAEPS 121_ QLLKS 126_ AIVHL 131_ INYQD 136_ DAELA 141_ TRALP 146_ ELTKL 151_ LNDED 156_ PVVVT 161_ KAAMI 166_ VNQLS 171_ KKEAS 176_ RRALM 181_ GSPQL 186_ VAAVV 191_ RTMQN 196_ TSDLD 201_ TARCT 206_ TSILH 211_ NLSHH 216_ REGLL 221_ AIFKS 226_ GGIPA 231_ LVRML 236_ SSPVE 241_ SVLFY 246_ AITTL 251_ HNLLL 256_ YQEGA 261_ KMAVR 266_ LADGL 271_ QKMVP 276_ LLNKN 281_ NPKFL 286_ AITTD 291_ CLQLL 296_ AYGNQ 301_ ESKLI 306_ ILANG 311_ GPQAL 316_ VQIMR 321_ NYSYE 326_ KLLWT 331_ TSRVL 336_ KVLSV 341_ CPSNK 346_ PAIVE 351_ AGGMQ 356_ ALGKH 361_ LTSNS 366_ PRLVQ 371_ NCLWT 376_ LRNLS 381_ DVATK 386_ QEGLE 391_ SVLKI 396_ LVNQL 401_ SVDDV 406_ NVLTC 411_ ATGTL 416_ SNLTC 421_ NNSKN 426_ KTLVT 431_ QNSGV 436_ EALIH 441_ AILRA 446_ GDKDD 451_ ITEPA 456_ VCALR 461_ HLTSR 466_ HPEAE 471_ MAQNS 476_ VRLNY 481_ GIPAI 486_ VKLLN 491_ QPNQW 496_ PLVKA 501_ TIGLI 506_ RNLAL 511_ CPANH 516_ APLQE 521_ AAVIP 526_ RLVQL 531_ LVKAH 536_ QDAQR 541_ HVAAG 546_ TQQPY 551_ TDGVR 556_ MEEIV 561_ EGCTG 566_ ALHIL 571_ ARDPM 576_ NRMEI 581_ FRLNT 586_ IPLFV 591_ QLLYS 596_ SVENI 601_ QRVAA 606_ GVLCE 611_ LAQDK 616_ EAADA 621_ IDAEG 626_ ASAPL 631_ MELLH 636_ SRNEG 641_ TATYA 646_ AAVLF 651_ RISED 656_ KNPDY 661_ RKRVS 666_ VELTN 671_ SLFKH 676_ DPAAW 681_ EAAQS 686_ MIPIN 691_ EPYGD 696_ DMDAT 701_ YRPMY 706_ SSDVP 711_ LDPLE 716_ MHMDM 721_ DGDYP 726_ IDTYS 731_ DGLRP 736_PYPTA
1: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity)