Aldo-keto reductase family 1 member B1 (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) (EC 1.1.1.21)
1_MASRL 6_ LLNNG 11_ AKMPI 16_ LGLGT 21_ WKSPP 26_ GQVTE 31_ AVKVA 36_ IDVGY 41_ RHIDC 46_ AHVYQ 51_ NENEV 56_ GVAIQ 61_ EKLRE 66_ QVVKR 71_ EELFI 76_ VSKLW 81_ CTYHE 86_ KGLVK 91_ GACQK 96_ TLSDL 101_ KLDYL 106_ DLYLI 111_ HWPTG 116_ FKPGK 121_ EFFPL 126_ DESGN 131_ VVPSD 136_ TNILD 141_ TWAAM 146_ EELVD 151_ EGLVK 156_ AIGIS 161_ NFNHL 166_ QVEMI 171_ LNKPG 176_ LKYKP 181_ AVNQI 186_ ECHPY 191_ LTQEK 196_ LIQYC 201_ QSKGI 206_ VVTAY 211_ SPLGS 216_ PDRPW 221_ AKPED 226_ PSLLE 231_ DPRIK 236_ AIAAK 241_ HNKTT 246_ AQVLI 251_ RFPMQ 256_ RNLVV 261_ IPKSV 266_ TPERI 271_ AENFK 276_ VFDFE 281_ LSSQD 286_ MTTLL 291_ SYNRN 296_ WRVCA 301_ LLSCT 306_ SHKDY 311_PFHEE
1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684)