Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog)
1_MELSE 6_ PIVEN 11_ GETEM 16_ SPEES 21_ WEHKE 26_ EISEA 31_ EPGGG 36_ SLGDG 41_ RPPEE 46_ SAHEM 51_ MEEEE 56_ EIPKP 61_ KSVVA 66_ PPGAP 71_ KKEHV 76_ NVVFI 81_ GHVDA 86_ GKSTI 91_ GGQIM 96_ YLTGM 101_ VDKRT 106_ LEKYE 111_ REAKE 116_ KNRET 121_ WYLSW 126_ ALDTN 131_ QEERD 136_ KGKTV 141_ EVGRA 146_ YFETE 151_ KKHFT 156_ ILDAP 161_ GHKSF 166_ VPNMI 171_ GGASQ 176_ ADLAV 181_ LVISA 186_ RKGEF 191_ ETGFE 196_ KGGQT 201_ REHAM 206_ LAKTA 211_ GVKHL 216_ IVLIN 221_ KMDDP 226_ TVNWS 231_ NERYE 236_ ECKEK 241_ LVPFL 246_ KKVGF 251_ NPKKD 256_ IHFMP 261_ CSGLT 266_ GANLK 271_ EQSDF 276_ CPWYI 281_ GLPFI 286_ PYLDN 291_ LPNFN 296_ RSVDG 301_ PIRLP 306_ IVDKY 311_ KDMGT 316_ VVLGK 321_ LESGS 326_ ICKGQ 331_ QLVMM 336_ PNKHN 341_ VEVLG 346_ ILSDD 351_ VETDT 356_ VAPGE 361_ NLKIR 366_ LKGIE 371_ EEEIL 376_ PGFIL 381_ CDPNN 386_ LCHSG 391_ RTFDA 396_ QIVII 401_ EHKSI 406_ ICPGY 411_ NAVLH 416_ IHTCI 421_ EEVEI 426_ TALIC 431_ LVDKK 436_ SGEKS 441_ KTRPR 446_ FVKQD 451_ QVCIA 456_ RLRTA 461_ GTICL 466_ ETFKD 471_ FPQMG 476_ RFTLR 481_ DEGKT 486_ IAIGK 491_VLKLV
1: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)