Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
1_MALLF 6_ LLPLV 11_ MQGVS 16_ RAEMG 21_ TADLG 26_ PSSVP 31_ TPTNV 36_ TIESY 41_ NMNPI 46_ VYWEY 51_ QIMPQ 56_ VPVFT 61_ VEVKN 66_ YGVKN 71_ SEWID 76_ ACINI 81_ SHHYC 86_ NISDH 91_ VGDPS 96_ NSLWV 101_ RVKAR 106_ VGQKE 111_ SAYAK 116_ SEEFA 121_ VCRDG 126_ KIGPP 131_ KLDIR 136_ KEEKQ 141_ IMIDI 146_ FHPSV 151_ FVNGD 156_ EQEVD 161_ YDPET 166_ TCYIR 171_ VYNVY 176_ VRMNG 181_ SEIQY 186_ KILTQ 191_ KEDDC 196_ DEIQC 201_ QLAIP 206_ VSSLN 211_ SQYCV 216_ SAEGV 221_ LHVWG 226_ VTTEK 231_ SKEVC 236_ ITIFN 241_ SSIKG 246_ SLWIP 251_ VVAAL 256_ LLFLV 261_ LSLVF 266_ ICFYI 271_ KKINP 276_ LKEKS 281_ IILPK 286_ SLISV 291_ VRSAT 296_ LETKP 301_ ESKYV 306_ SLITS 311_ YQPFS 316_ LEKEV 321_ VCEEP 326_ LSPAT 331_ VPGMH 336_ TEDNP 341_ GKVEH 346_ TEELS 351_ SITEV 356_ VTTEE 361_ NIPDV 366_ VPGSH 371_ LTPIE 376_ RESSS 381_ PLSSN 386_ QSEPG 391_ SIALN 396_ SYHSR 401_ NCSES 406_ DHSRN 411_ GFDTD 416_ SSCLE 421_ SHSSL 426_ SDSEF 431_ PPNNK 436_ GEIKT 441_ EGQEL 446_ ITVIK 451_ APTSF 456_ GYDKP 461_ HVLVD 466_ LLVDD 471_ SGKES 476_ LIGYR 481_PTEDS
1: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity)