Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]
1_MRAAP 6_ LLLAR 11_ AASLS 16_ LGFLF 21_ LLFFW 26_ LDRSV 31_ LAKEL 36_ KFVTL 41_ VFRHG 46_ DRSPI 51_ DTFPT 56_ DPIKE 61_ SSWPQ 66_ GFGQL 71_ TQLGM 76_ EQHYE 81_ LGEYI 86_ RKRYR 91_ KFLNE 96_ SYKHE 101_ QVYIR 106_ STDVD 111_ RTLMS 116_ AMTNL 121_ AALFP 126_ PEGVS 131_ IWNPI 136_ LLWQP 141_ IPVHT 146_ VPLSE 151_ DQLLY 156_ LPFRN 161_ CPRFQ 166_ ELESE 171_ TLKSE 176_ EFQKR 181_ LHPYK 186_ DFIAT 191_ LGKLS 196_ GLHGQ 201_ DLFGI 206_ WSKVY 211_ DPLYC 216_ ESVHN 221_ FTLPS 226_ WATED 231_ TMTKL 236_ RELSE 241_ LSLLS 246_ LYGIH 251_ KQKEK 256_ SRLQG 261_ GVLVN 266_ EILNH 271_ MKRAT 276_ QIPSY 281_ KKLIM 286_ YSAHD 291_ TTVSG 296_ LQMAL 301_ DVYNG 306_ LLPPY 311_ ASCHL 316_ TELYF 321_ EKGEY 326_ FVEMY 331_ YRNET 336_ QHEPY 341_ PLMLP 346_ GCSPS 351_ CPLER 356_ FAELV 361_ GPVIP 366_ QDWST 371_ ECMTT 376_ NSHQG 381_TEDST
1: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042)
2: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling (PubMed:20498373). In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity)
3: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection (PubMed:18083097, PubMed:19451623, PubMed:19897482). SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea (PubMed:19451623). Target cell attachment and enhancement of HIV infection is inhibited by surfen (PubMed:19897482). Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection (PubMed:19403677)