Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)
1_MAQRM 6_ TTQLL 11_ LLLVW 16_ VAVVG 21_ EAQTR 26_ IAWAR 31_ TELLN 36_ VCMNA 41_ KHHKE 46_ KPGPE 51_ DKLHE 56_ QCRPW 61_ RKNAC 66_ CSTNT 71_ SQEAH 76_ KDVSY 81_ LYRFN 86_ WNHCG 91_ EMAPA 96_ CKRHF 101_ IQDTC 106_ LYECS 111_ PNLGP 116_ WIQQV 121_ DQSWR 126_ KERVL 131_ NVPLC 136_ KEDCE 141_ QWWED 146_ CRTSY 151_ TCKSN 156_ WHKGW 161_ NWTSG 166_ FNKCA 171_ VGAAC 176_ QPFHF 181_ YFPTP 186_ TVLCN 191_ EIWTH 196_ SYKVS 201_ NYSRG 206_ SGRCI 211_ QMWFD 216_ PAQGN 221_ PNEEV 226_ ARFYA 231_ AAMSG 236_ AGPWA 241_ AWPFL 246_ LSLAL 251_MLLWL
1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity)