Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
1_MKFKL 6_ HVNSA 11_ RQYKD 16_ LWNMS 21_ DDKPF 26_ LCTAP 31_ GCGQR 36_ FTNED 41_ HLAVH 46_ KHKHE 51_ MTLKF 56_ GPARN 61_ DSVIV 66_ ADQTP 71_ TPTRF 76_ LKNCE 81_ EVGLF 86_ NELAS 91_ PFENE 96_ FKKAS 101_ EDDIK 106_ KMPLD 111_ LSPLA 116_ TPIIR 121_ SKIEE 126_ PSVVE 131_ TTHQD 136_ SPLPH 141_ PESTT 146_ SDEKE 151_ VPLAQ 156_ TAQPT 161_ SAIVR 166_ PASLQ 171_ VPNVL 176_ LTSSD 181_ SSVII 186_ QQAVP 191_ SPTSS 196_ TVITQ 201_ APSSN 206_ RPIVP 211_ VPGPF 216_ PLLLH 221_ LPNGQ 226_ TMPVA 231_ IPASI 236_ TSSNV 241_ HVPAA 246_ VPLVR 251_ PVTMV 256_ PSVPG 261_ IPGPS 266_ SPQPV 271_ QSEAK 276_ MRLKA 281_ ALTQQ 286_ HPPVT 291_ NGDTV 296_ KGHGS 301_ GLVRT 306_ QSEES 311_ RPQSL 316_ QQPAT 321_ STTET 326_ PASPA 331_ HTTPQ 336_ TQSTS 341_ GRRRR 346_ AANED 351_ PDEKR 356_ RKFLE 361_ RNRAA 366_ ASRCR 371_ QKRKV 376_ WVQSL 381_ EKKAE 386_ DLSSL 391_ NGQLQ 396_ SEVTL 401_ LRNEV 406_ AQLKQ 411_ LLLAH 416_ KDCPV 421_ TAMQK 426_ KSGYH 431_ TADKD 436_ DSSED 441_ ISVPS 446_ SPHTE 451_ AIQHS 456_ SVSTS 461_ NGVSS 466_ TSKAE 471_ AVATS 476_ VLTQM 481_ ADQST 486_ EPALS 491_ QIVMA 496_PSSQS
1: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type