Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)
1_MEGQR 6_ WLPLE 11_ ANPEV 16_ TNQFL 21_ KQLGL 26_ HPNWQ 31_ FVDVY 36_ GMDPE 41_ LLSMV 46_ PRPVC 51_ AVLLL 56_ FPITE 61_ KYEVF 66_ RTEEE 71_ EKIKS 76_ QGQDV 81_ TSSVY 86_ FMKQT 91_ ISNAC 96_ GTIGL 101_ IHAIA 106_ NNKDK 111_ MHFES 116_ GSTLK 121_ KFLEE 126_ SVSMS 131_ PEERA 136_ RYLEN 141_ YDAIR 146_ VTHET 151_ SAHEG 156_ QTEAP 161_ SIDEK 166_ VDLHF 171_ IALVH 176_ VDGHL 181_ YELDG 186_ RKPFP 191_ INHGE 196_ TSDET 201_ LLEDA 206_ IEVCK 211_ KFMER 216_ DPDEL 221_RFNAI
1: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders