Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)
1_MILSN 6_ TTAVT 11_ PFLTK 16_ LWQET 21_ VQQGG 26_ NMSGL 31_ ARRSP 36_ RSSDG 41_ KLEAL 46_ YVLMV 51_ LGFFG 56_ FFTLG 61_ IMLSY 66_ IRSKK 71_ LEHSN 76_ DPFNV 81_ YIESD 86_ AWQEK 91_ DKAYV 96_ QARVL 101_ ESYRS 106_ CYVVE 111_ NHLAI 116_ EQPNT 121_HLPET
1: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:19219384, PubMed:20533308, PubMed:9230439). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization (PubMed:20533308). The outward current reaches its steady state only after 50 seconds (Probable). Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:9230439)