Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)
1_MEPPG 6_ RRECP 11_ FPSWR 16_ FPGLL 21_ LAAMV 26_ LLLYS 31_ FSDAC 36_ EEPPT 41_ FEAME 46_ LIGKP 51_ KPYYE 56_ IGERV 61_ DYKCK 66_ KGYFY 71_ IPPLA 76_ THTIC 81_ DRNHT 86_ WLPVS 91_ DDACY 96_ RETCP 101_ YIRDP 106_ LNGQA 111_ VPANG 116_ TYEFG 121_ YQMHF 126_ ICNEG 131_ YYLIG 136_ EEILY 141_ CELKG 146_ SVAIW 151_ SGKPP 156_ ICEKV 161_ LCTPP 166_ PKIKN 171_ GKHTF 176_ SEVEV 181_ FEYLD 186_ AVTYS 191_ CDPAP 196_ GPDPF 201_ SLIGE 206_ STIYC 211_ GDNSV 216_ WSRAA 221_ PECKV 226_ VKCRF 231_ PVVEN 236_ GKQIS 241_ GFGKK 246_ FYYKA 251_ TVMFE 256_ CDKGF 261_ YLDGS 266_ DTIVC 271_ DSNST 276_ WDPPV 281_ PKCLK 286_ VLPPS 291_ STKPP 296_ ALSHS 301_ VSTSS 306_ TTKSP 311_ ASSAS 316_ GPRPT 321_ YKPPV 326_ SNYPG 331_ YPKPE 336_ EGILD 341_ SLDVW 346_ VIAVI 351_ VIAIV 356_ VGVAV 361_ ICVVP 366_ YRYLQ 371_ RRKKK 376_ GTYLT 381_ DETHR 386_EVKFT
1: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity
2: (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells
3: (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3
4: (Microbial infection) Acts as a receptor for cultured Measles virus
5: (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6
6: (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894)