Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
1_MANCE 6_ RTFIA 11_ IKPDG 16_ VQRGL 21_ VGEII 26_ KRFEQ 31_ KGFRL 36_ VGLKF 41_ MQASE 46_ DLLKE 51_ HYVDL 56_ KDRPF 61_ FAGLV 66_ KYMHS 71_ GPVVA 76_ MVWEG 81_ LNVVK 86_ TGRVM 91_ LGETN 96_ PADSK 101_ PGTIR 106_ GDFCI 111_ QVGRN 116_ IIHGS 121_ DSVES 126_ AEKEI 131_ GLWFH 136_ PEELV 141_ DYTSC 146_AQNWI
1: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair