Cytochrome P450 11B1, mitochondrial (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B1) (EC 1.14.15.4)
1_MALRA 6_ KAEVC 11_ MAVPW 16_ LSLQR 21_ AQALG 26_ TRAAR 31_ VPRTV 36_ LPFEA 41_ MPRRP 46_ GNRWL 51_ RLLQI 56_ WREQG 61_ YEDLH 66_ LEVHQ 71_ TFQEL 76_ GPIFR 81_ YDLGG 86_ AGMVC 91_ VMLPE 96_ DVEKL 101_ QQVDS 106_ LHPHR 111_ MSLEP 116_ WVAYR 121_ QHRGH 126_ KCGVF 131_ LLNGP 136_ EWRFN 141_ RLRLN 146_ PEVLS 151_ PNAVQ 156_ RFLPM 161_ VDAVA 166_ RDFSQ 171_ ALKKK 176_ VLQNA 181_ RGSLT 186_ LDVQP 191_ SIFHY 196_ TIEAS 201_ NLALF 206_ GERLG 211_ LVGHS 216_ PSSAS 221_ LNFLH 226_ ALEVM 231_ FKSTV 236_ QLMFM 241_ PRSLS 246_ RWTSP 251_ KVWKE 256_ HFEAW 261_ DCIFQ 266_ YGDNC 271_ IQKIY 276_ QELAF 281_ SRPQQ 286_ YTSIV 291_ AELLL 296_ NAELS 301_ PDAIK 306_ ANSME 311_ LTAGS 316_ VDTTV 321_ FPLLM 326_ TLFEL 331_ ARNPN 336_ VQQAL 341_ RQESL 346_ AAAAS 351_ ISEHP 356_ QKATT 361_ ELPLL 366_ RAALK 371_ ETLRL 376_ YPVGL 381_ FLERV 386_ ASSDL 391_ VLQNY 396_ HIPAG 401_ TLVRV 406_ FLYSL 411_ GRNPA 416_ LFPRP 421_ ERYNP 426_ QRWLD 431_ IRGSG 436_ RNFYH 441_ VPFGF 446_ GMRQC 451_ LGRRL 456_ AEAEM 461_ LLLLH 466_ HVLKH 471_ LQVET 476_ LTQED 481_ IKMVY 486_ SFILR 491_ PSMFP 496_LLTFR
1: A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:12530636, PubMed:1518866, PubMed:1775135, PubMed:18215163, PubMed:23322723). Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19 (By similarity). Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone (PubMed:12530636, PubMed:1518866, PubMed:1775135, PubMed:18215163, PubMed:23322723). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:18215163). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone (PubMed:23322723). Could also be involved in the androgen metabolic pathway (Probable)