Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
1_MNFLL 6_ SWVHW 11_ SLALL 16_ LYLHH 21_ AKWSQ 26_ AAPMA 31_ EGGGQ 36_ NHHEV 41_ VKFMD 46_ VYQRS 51_ YCHPI 56_ ETLVD 61_ IFQEY 66_ PDEIE 71_ YIFKP 76_ SCVPL 81_ MRCGG 86_ CCNDE 91_ GLECV 96_ PTEES 101_ NITMQ 106_ IMRIK 111_ PHQGQ 116_ HIGEM 121_ SFLQH 126_ NKCEC 131_ RPKKD 136_ RARQE 141_ KKSVR 146_ GKGKG 151_ QKRKR 156_ KKSRY 161_ KSWSV 166_ YVGAR 171_ CCLMP 176_ WSLPG 181_ PHPCG 186_ PCSER 191_ RKHLF 196_ VQDPQ 201_ TCKCS 206_ CKNTD 211_ SRCKA 216_ RQLEL 221_ NERTC 226_RCDKP
1: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)
2: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth (PubMed:34530889). Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437)
3: Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth