Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
1_MNQPQ 6_ RMAPV 11_ GTDKE 16_ LSDLL 21_ DFSMM 26_ FPLPV 31_ TNGKG 36_ RPASL 41_ AGAQF 46_ GGSGL 51_ EDRPS 56_ SGSWG 61_ SGDQS 66_ SSSFD 71_ PSRTF 76_ SEGTH 81_ FTESH 86_ SSLSS 91_ STFLG 96_ PGLGG 101_ KSGER 106_ GAYAS 111_ FGRDA 116_ GVGGL 121_ TQAGF 126_ LSGEL 131_ ALNSP 136_ GPLSP 141_ SGMKG 146_ TSQYY 151_ PSYSG 156_ SSRRR 161_ AADGS 166_ LDTQP 171_ KKVRK 176_ VPPGL 181_ PSSVY 186_ PPSSG 191_ EDYGR 196_ DATAY 201_ PSAKT 206_ PSSTY 211_ PAPFY 216_ VADGS 221_ LHPSA 226_ ELWSP 231_ PGQAG 236_ FGPML 241_ GGGSS 246_ PLPLP 251_ PGSGP 256_ VGSSG 261_ SSSTF 266_ GGLHQ 271_ HERMG 276_ YQLHG 281_ AEVNG 286_ GLPSA 291_ SSFSS 296_ APGAT 301_ YGGVS 306_ SHTPP 311_ VSGAD 316_ SLLGS 321_ RGTTA 326_ GSSGD 331_ ALGKA 336_ LASIY 341_ SPDHS 346_ SNNFS 351_ SSPST 356_ PVGSP 361_ QGLAG 366_ TSQWP 371_ RAGAP 376_ GALSP 381_ SYDGG 386_ LHGLQ 391_ SKIED 396_ HLDEA 401_ IHVLR 406_ SHAVG 411_ TAGDM 416_ HTLLP 421_ GHGAL 426_ ASGFT 431_ GPMSL 436_ GGRHA 441_ GLVGG 446_ SHPED 451_ GLAGS 456_ TSLMH 461_ NHAAL 466_ PSQPG 471_ TLPDL 476_ SRPPD 481_ SYSGL 486_ GRAGA 491_ TAAAS 496_ EIKRE 501_ EKEDE 506_ ENTSA 511_ ADHSE 516_ EEKKE 521_ LKAPR 526_ ARTSP 531_ DEDED 536_ DLLPP 541_ EQKAE 546_ REKER 551_ RVANN 556_ ARERL 561_ RVRDI 566_ NEAFK 571_ ELGRM 576_ CQLHL 581_ NSEKP 586_ QTKLL 591_ ILHQA 596_ VSVIL 601_ NLEQQ 606_ VRERN 611_ LNPKA 616_ ACLKR 621_ REEEK 626_ VSGVV 631_ GDPQM 636_ VLSAP 641_ HPGLS 646_EAHNP
1: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity)
2: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity