Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein)
1_MEFPG 6_ LGSLG 11_ TSEPL 16_ PQFVD 21_ PALVS 26_ STPES 31_ GVFFP 36_ SGPEG 41_ LDAAA 46_ SSTAP 51_ STATA 56_ AAAAL 61_ AYYRD 66_ AEAYR 71_ HSPVF 76_ QVYPL 81_ LNCME 86_ GIPGG 91_ SPYAG 96_ WAYGK 101_ TGLYP 106_ ASTVC 111_ PTRED 116_ SPPQA 121_ VEDLD 126_ GKGST 131_ SFLET 136_ LKTER 141_ LSPDL 146_ LTLGP 151_ ALPSS 156_ LPVPN 161_ SAYGG 166_ PDFSS 171_ TFFSP 176_ TGSPL 181_ NSAAY 186_ SSPKL 191_ RGTLP 196_ LPPCE 201_ ARECV 206_ NCGAT 211_ ATPLW 216_ RRDRT 221_ GHYLC 226_ NACGL 231_ YHKMN 236_ GQNRP 241_ LIRPK 246_ KRLIV 251_ SKRAG 256_ TQCTN 261_ CQTTT 266_ TTLWR 271_ RNASG 276_ DPVCN 281_ ACGLY 286_ YKLHQ 291_ VNRPL 296_ TMRKD 301_ GIQTR 306_ NRKAS 311_ GKGKK 316_ KRGSS 321_ LGGTG 326_ AAEGP 331_ AGGFM 336_ VVAGG 341_ SGSGN 346_ CGEVA 351_ SGLTL 356_ GPPGT 361_ AHLYQ 366_ GLGPV 371_ VLSGP 376_ VSHLM 381_ PFPGP 386_ LLGSP 391_ TGSFP 396_ TGPMP 401_ PTTST 406_TVVAP
1: Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781)