Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
1_MGAAA 6_ RTLRL 11_ ALGLL 16_ LLATL 21_ LRPAD 26_ ACSCS 31_ PVHPQ 36_ QAFCN 41_ ADVVI 46_ RAKAV 51_ SEKEV 56_ DSGND 61_ IYGNP 66_ IKRIQ 71_ YEIKQ 76_ IKMFK 81_ GPEKD 86_ IEFIY 91_ TAPSS 96_ AVCGV 101_ SLDVG 106_ GKKEY 111_ LIAGK 116_ AEGDG 121_ KMHIT 126_ LCDFI 131_ VPWDT 136_ LSTTQ 141_ KKSLN 146_ HRYQM 151_ GCECK 156_ ITRCP 161_ MIPCY 166_ ISSPD 171_ ECLWM 176_ DWVTE 181_ KNING 186_ HQAKF 191_ FACIK 196_ RSDGS 201_ CAWYR 206_ GAAPP 211_KQEFL
1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19