Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (EC 1.13.11.-) (Linoleate 13S-lipoxygenase) (EC 1.13.11.12)
1_MGLYR 6_ IRVST 11_ GASLY 16_ AGSNN 21_ QVQLW 26_ LVGQH 31_ GEAAL 36_ GKRLW 41_ PARGK 46_ ETELK 51_ VEVPE 56_ YLGPL 61_ LFVKL 66_ RKRHL 71_ LKDDA 76_ WFCNW 81_ ISVQG 86_ PGAGD 91_ EVRFP 96_ CYRWV 101_ EGNGV 106_ LSLPE 111_ GTGRT 116_ VGEDP 121_ QGLFQ 126_ KHREE 131_ ELEER 136_ RKLYR 141_ WGNWK 146_ DGLIL 151_ NMAGA 156_ KLYDL 161_ PVDER 166_ FLEDK 171_ RVDFE 176_ VSLAK 181_ GLADL 186_ AIKDS 191_ LNVLT 196_ CWKDL 201_ DDFNR 206_ IFWCG 211_ QSKLA 216_ ERVRD 221_ SWKED 226_ ALFGY 231_ QFLNG 236_ ANPVV 241_ LRRSA 246_ HLPAR 251_ LVFPP 256_ GMEEL 261_ QAQLE 266_ KELEG 271_ GTLFE 276_ ADFSL 281_ LDGIK 286_ ANVIL 291_ CSQQH 296_ LAAPL 301_ VMLKL 306_ QPDGK 311_ LLPMV 316_ IQLQL 321_ PRTGS 326_ PPPPL 331_ FLPTD 336_ PPMAW 341_ LLAKC 346_ WVRSS 351_ DFQLH 356_ ELQSH 361_ LLRGH 366_ LMAEV 371_ IVVAT 376_ MRCLP 381_ SIHPI 386_ FKLII 391_ PHLRY 396_ TLEIN 401_ VRART 406_ GLVSD 411_ MGIFD 416_ QIMST 421_ GGGGH 426_ VQLLK 431_ QAGAF 436_ LTYSS 441_ FCPPD 446_ DLADR 451_ GLLGV 456_ KSSFY 461_ AQDAL 466_ RLWEI 471_ IYRYV 476_ EGIVS 481_ LHYKT 486_ DVAVK 491_ DDPEL 496_ QTWCR 501_ EITEI 506_ GLQGA 511_ QDRGF 516_ PVSLQ 521_ ARDQV 526_ CHFVT 531_ MCIFT 536_ CTGQH 541_ ASVHL 546_ GQLDW 551_ YSWVP 556_ NAPCT 561_ MRLPP 566_ PTTKD 571_ ATLET 576_ VMATL 581_ PNFHQ 586_ ASLQM 591_ SITWQ 596_ LGRRQ 601_ PVMVA 606_ VGQHE 611_ EEYFS 616_ GPEPK 621_ AVLKK 626_ FREEL 631_ AALDK 636_ EIEIR 641_ NAKLD 646_ MPYEY 651_ LRPSV 656_VENSV
1: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:25293588, PubMed:32404334, PubMed:8334154). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:8334154). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (PubMed:8334154). May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (PubMed:25293588). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed:21831839)