Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
1_MPGPR 6_ RPAGS 11_ RLRLL 16_ LLLLL 21_ PPLLL 26_ LLRGS 31_ HAGNL 36_ TVAVV 41_ LPLAN 46_ TSYPW 51_ SWARV 56_ GPAVE 61_ LALAQ 66_ VKARP 71_ DLLPG 76_ WTVRT 81_ VLGSS 86_ ENALG 91_ VCSDT 96_ AAPLA 101_ AVDLK 106_ WEHNP 111_ AVFLG 116_ PGCVY 121_ AAAPV 126_ GRFTA 131_ HWRVP 136_ LLTAG 141_ APALG 146_ FGVKD 151_ EYALT 156_ TRAGP 161_ SYAKL 166_ GDFVA 171_ ALHRR 176_ LGWER 181_ QALML 186_ YAYRP 191_ GDEEH 196_ CFFLV 201_ EGLFM 206_ RVRDR 211_ LNITV 216_ DHLEF 221_ AEDDL 226_ SHYTR 231_ LLRTM 236_ PRKGR 241_ VIYIC 246_ SSPDA 251_ FRTLM 256_ LLALE 261_ AGLCG 266_ EDYVF 271_ FHLDI 276_ FGQSL 281_ QGGQG 286_ PAPRR 291_ PWERG 296_ DGQDV 301_ SARQA 306_ FQAAK 311_ IITYK 316_ DPDNP 321_ EYLEF 326_ LKQLK 331_ HLAYE 336_ QFNFT 341_ MEDGL 346_ VNTIP 351_ ASFHD 356_ GLLLY 361_ IQAVT 366_ ETLAH 371_ GGTVT 376_ DGENI 381_ TQRMW 386_ NRSFQ 391_ GVTGY 396_ LKIDS 401_ SGDRE 406_ TDFSL 411_ WDMDP 416_ ENGAF 421_ RVVLN 426_ YNGTS 431_ QELVA 436_ VSGRK 441_ LNWPL 446_ GYPPP 451_ DIPKC 456_ GFDNE 461_ DPACN 466_ QDHLS 471_ TLEVL 476_ ALVGS 481_ LSLLG 486_ ILIVS 491_ FFIYR 496_ KMQLE 501_ KELAS 506_ ELWRV 511_ RWEDV 516_ EPSSL 521_ ERHLR 526_ SAGSR 531_ LTLSG 536_ RGSNY 541_ GSLLT 546_ TEGQF 551_ QVFAK 556_ TAYYK 561_ GNLVA 566_ VKRVN 571_ RKRIE 576_ LTRKV 581_ LFELK 586_ HMRDV 591_ QNEHL 596_ TRFVG 601_ ACTDP 606_ PNICI 611_ LTEYC 616_ PRGSL 621_ QDILE 626_ NESIT 631_ LDWMF 636_ RYSLT 641_ NDIVK 646_ GMLFL 651_ HNGAI 656_ CSHGN 661_ LKSSN 666_ CVVDG 671_ RFVLK 676_ ITDYG 681_ LESFR 686_ DLDPE 691_ QGHTV 696_ YAKKL 701_ WTAPE 706_ LLRMA 711_ SPPVR 716_ GSQAG 721_ DVYSF 726_ GIILQ 731_ EIALR 736_ SGVFH 741_ VEGLD 746_ LSPKE 751_ IIERV 756_ TRGEQ 761_ PPFRP 766_ SLALQ 771_ SHLEE 776_ LGLLM 781_ QRCWA 786_ EDPQE 791_ RPPFQ 796_ QIRLT 801_ LRKFN 806_ RENSS 811_ NILDN 816_ LLSRM 821_ EQYAN 826_ NLEEL 831_ VEERT 836_ QAYLE 841_ EKRKA 846_ EALLY 851_ QILPH 856_ SVAEQ 861_ LKRGE 866_ TVQAE 871_ AFDSV 876_ TIYFS 881_ DIVGF 886_ TALSA 891_ ESTPM 896_ QVVTL 901_ LNDLY 906_ TCFDA 911_ VIDNF 916_ DVYKV 921_ ETIGD 926_ AYMVV 931_ SGLPV 936_ RNGRL 941_ HACEV 946_ ARMAL 951_ ALLDA 956_ VRSFR 961_ IRHRP 966_ QEQLR 971_ LRIGI 976_ HTGPV 981_ CAGVV 986_ GLKMP 991_ RYCLF 996_ GDTVN 1001_ TASRM 1006_ ESNGE 1011_ ALKIH 1016_ LSSET 1021_ KAVLE 1026_ EFGGF 1031_ ELELR 1036_ GDVEM 1041_ KGKGK 1046_ VRTYW 1051_ LLGER 1056_GSSTR
1: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499)