CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
1_MDKFW 6_ WHAAW 11_ GLCLV 16_ PLSLA 21_ QIDLN 26_ ITCRF 31_ AGVFH 36_ VEKNG 41_ RYSIS 46_ RTEAA 51_ DLCKA 56_ FNSTL 61_ PTMAQ 66_ MEKAL 71_ SIGFE 76_ TCRYG 81_ FIEGH 86_ VVIPR 91_ IHPNS 96_ ICAAN 101_ NTGVY 106_ ILTSN 111_ TSQYD 116_ TYCFN 121_ ASAPP 126_ EEDCT 131_ SVTDL 136_ PNAFD 141_ GPITI 146_ TIVNR 151_ DGTRY 156_ VQKGE 161_ YRTNP 166_ EDIYP 171_ SNPTD 176_ DDVSS 181_ GSSSE 186_ RSSTS 191_ GGYIF 196_ YTFST 201_ VHPIP 206_ DEDSP 211_ WITDS 216_ TDRIP 221_ ATTLM 226_ STSAT 231_ ATETA 236_ TKRQE 241_ TWDWF 246_ SWLFL 251_ PSESK 256_ NHLHT 261_ TTQMA 266_ GTSSN 271_ TISAG 276_ WEPNE 281_ ENEDE 286_ RDRHL 291_ SFSGS 296_ GIDDD 301_ EDFIS 306_ STIST 311_ TPRAF 316_ DHTKQ 321_ NQDWT 326_ QWNPS 331_ HSNPE 336_ VLLQT 341_ TTRMT 346_ DVDRN 351_ GTTAY 356_ EGNWN 361_ PEAHP 366_ PLIHH 371_ EHHEE 376_ EETPH 381_ STSTI 386_ QATPS 391_ STTEE 396_ TATQK 401_ EQWFG 406_ NRWHE 411_ GYRQT 416_ PKEDS 421_ HSTTG 426_ TAAAS 431_ AHTSH 436_ PMQGR 441_ TTPSP 446_ EDSSW 451_ TDFFN 456_ PISHP 461_ MGRGH 466_ QAGRR 471_ MDMDS 476_ SHSIT 481_ LQPTA 486_ NPNTG 491_ LVEDL 496_ DRTGP 501_ LSMTT 506_ QQSNS 511_ QSFST 516_ SHEGL 521_ EEDKD 526_ HPTTS 531_ TLTSS 536_ NRNDV 541_ TGGRR 546_ DPNHS 551_ EGSTT 556_ LLEGY 561_ TSHYP 566_ HTKES 571_ RTFIP 576_ VTSAK 581_ TGSFG 586_ VTAVT 591_ VGDSN 596_ SNVNR 601_ SLSGD 606_ QDTFH 611_ PSGGS 616_ HTTHG 621_ SESDG 626_ HSHGS 631_ QEGGA 636_ NTTSG 641_ PIRTP 646_ QIPEW 651_ LIILA 656_ SLLAL 661_ ALILA 666_ VCIAV 671_ NSRRR 676_ CGQKK 681_ KLVIN 686_ SGNGA 691_ VEDRK 696_ PSGLN 701_ GEASK 706_ SQEMV 711_ HLVNK 716_ ESSET 721_ PDQFM 726_ TADET 731_ RNLQN 736_VDMKI
1: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640)