Histone H2AX (H2a/x) (Histone H2A.X)
1_MSGRG 6_ KTGGK 11_ ARAKA 16_ KSRSS 21_ RAGLQ 26_ FPVGR 31_ VHRLL 36_ RKGHY 41_ AERVG 46_ AGAPV 51_ YLAAV 56_ LEYLT 61_ AEILE 66_ LAGNA 71_ ARDNK 76_ KTRII 81_ PRHLQ 86_ LAIRN 91_ DEELN 96_ KLLGG 101_ VTIAQ 106_ GGVLP 111_ NIQAV 116_ LLPKK 121_ TSATV 126_ GPKAP 131_ SGGKK 136_ATQAS
1: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation