Gene name: ACAN

Uniprot entry:

P16112

Protein names:

Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]

Protein sequence:

1_MTTLL 6_ WVFVT 11_ LRVIT 16_ AAVTV 21_ ETSDH 26_ DNSLS 31_ VSIPQ 36_ PSPLR 41_ VLLGT 46_ SLTIP 51_ CYFID 56_ PMHPV 61_ TTAPS 66_ TAPLA 71_ PRIKW 76_ SRVSK 81_ EKEVV 86_ LLVAT 91_ EGRVR 96_ VNSAY 101_ QDKVS 106_ LPNYP 111_ AIPSD 116_ ATLEV 121_ QSLRS 126_ NDSGV 131_ YRCEV 136_ MHGIE 141_ DSEAT 146_ LEVVV 151_ KGIVF 156_ HYRAI 161_ STRYT 166_ LDFDR 171_ AQRAC 176_ LQNSA 181_ IIATP 186_ EQLQA 191_ AYEDG 196_ FHQCD 201_ AGWLA 206_ DQTVR 211_ YPIHT 216_ PREGC 221_ YGDKD 226_ EFPGV 231_ RTYGI 236_ RDTNE 241_ TYDVY 246_ CFAEE 251_ MEGEV 256_ FYATS 261_ PEKFT 266_ FQEAA 271_ NECRR 276_ LGARL 281_ ATTGQ 286_ LYLAW 291_ QAGMD 296_ MCSAG 301_ WLADR 306_ SVRYP 311_ ISKAR 316_ PNCGG 321_ NLLGV 326_ RTVYV 331_ HANQT 336_ GYPDP 341_ SSRYD 346_ AICYT 351_ GEDFV 356_ DIPEN 361_ FFGVG 366_ GEEDI 371_ TVQTV 376_ TWPDM 381_ ELPLP 386_ RNITE 391_ GEARG 396_ SVILT 401_ VKPIF 406_ EVSPS 411_ PLEPE 416_ EPFTF 421_ APEIG 426_ ATAFA 431_ EVENE 436_ TGEAT 441_ RPWGF 446_ PTPGL 451_ GPATA 456_ FTSED 461_ LVVQV 466_ TAVPG 471_ QPHLP 476_ GGVVF 481_ HYRPG 486_ PTRYS 491_ LTFEE 496_ AQQAC 501_ LRTGA 506_ VIASP 511_ EQLQA 516_ AYEAG 521_ YEQCD 526_ AGWLR 531_ DQTVR 536_ YPIVS 541_ PRTPC 546_ VGDKD 551_ SSPGV 556_ RTYGV 561_ RPSTE 566_ TYDVY 571_ CFVDR 576_ LEGEV 581_ FFATR 586_ LEQFT 591_ FQEAL 596_ EFCES 601_ HNATL 606_ ATTGQ 611_ LYAAW 616_ SRGLD 621_ KCYAG 626_ WLADG 631_ SLRYP 636_ IVTPR 641_ PACGG 646_ DKPGV 651_ RTVYL 656_ YPNQT 661_ GLPDP 666_ LSRHH 671_ AFCFR 676_ GISAV 681_ PSPGE 686_ EEGGT 691_ PTSPS 696_ GVEEW 701_ IVTQV 706_ VPGVA 711_ AVPVE 716_ EETTA 721_ VPSGE 726_ TTAIL 731_ EFTTE 736_ PENQT 741_ EWEPA 746_ YTPVG 751_ TSPLP 756_ GILPT 761_ WPPTG 766_ AATEE 771_ STEGP 776_ SATEV 781_ PSASE 786_ EPSPS 791_ EVPFP 796_ SEEPS 801_ PSEEP 806_ FPSVR 811_ PFPSV 816_ ELFPS 821_ EEPFP 826_ SKEPS 831_ PSEEP 836_ SASEE 841_ PYTPS 846_ PPVPS 851_ WTELP 856_ SSGEE 861_ SGAPD 866_ VSGDF 871_ TGSGD 876_ VSGHL 881_ DFSGQ 886_ LSGDR 891_ ASGLP 896_ SGDLD 901_ SSGLT 906_ STVGS 911_ GLPVE 916_ SGLPS 921_ GDEER 926_ IEWPS 931_ TPTVG 936_ ELPSG 941_ AEILE 946_ GSASG 951_ VGDLS 956_ GLPSG 961_ EVLET 966_ SASGV 971_ GDLSG 976_ LPSGE 981_ VLETT 986_ APGVE 991_ DISGL 996_ PSGEV 1001_ LETTA 1006_ PGVED 1011_ ISGLP 1016_ SGEVL 1021_ ETTAP 1026_ GVEDI 1031_ SGLPS 1036_ GEVLE 1041_ TTAPG 1046_ VEDIS 1051_ GLPSG 1056_ EVLET 1061_ TAPGV 1066_ EDISG 1071_ LPSGE 1076_ VLETT 1081_ APGVE 1086_ DISGL 1091_ PSGEV 1096_ LETAA 1101_ PGVED 1106_ ISGLP 1111_ SGEVL 1116_ ETAAP 1121_ GVEDI 1126_ SGLPS 1131_ GEVLE 1136_ TAAPG 1141_ VEDIS 1146_ GLPSG 1151_ EVLET 1156_ AAPGV 1161_ EDISG 1166_ LPSGE 1171_ VLETA 1176_ APGVE 1181_ DISGL 1186_ PSGEV 1191_ LETAA 1196_ PGVED 1201_ ISGLP 1206_ SGEVL 1211_ ETAAP 1216_ GVEDI 1221_ SGLPS 1226_ GEVLE 1231_ TAAPG 1236_ VEDIS 1241_ GLPSG 1246_ EVLET 1251_ AAPGV 1256_ EDISG 1261_ LPSGE 1266_ VLETA 1271_ APGVE 1276_ DISGL 1281_ PSGEV 1286_ LETAA 1291_ PGVED 1296_ ISGLP 1301_ SGEVL 1306_ ETAAP 1311_ GVEDI 1316_ SGLPS 1321_ GEVLE 1326_ TAAPG 1331_ VEDIS 1336_ GLPSG 1341_ EVLET 1346_ AAPGV 1351_ EDISG 1356_ LPSGE 1361_ VLETA 1366_ APGVE 1371_ DISGL 1376_ PSGEV 1381_ LETAA 1386_ PGVED 1391_ ISGLP 1396_ SGEVL 1401_ ETTAP 1406_ GVEEI 1411_ SGLPS 1416_ GEVLE 1421_ TTAPG 1426_ VDEIS 1431_ GLPSG 1436_ EVLET 1441_ TAPGV 1446_ EEISG 1451_ LPSGE 1456_ VLETS 1461_ TSAVG 1466_ DLSGL 1471_ PSGGE 1476_ VLEIS 1481_ VSGVE 1486_ DISGL 1491_ PSGEV 1496_ VETSA 1501_ SGIED 1506_ VSELP 1511_ SGEGL 1516_ ETSAS 1521_ GVEDL 1526_ SRLPS 1531_ GEEVL 1536_ EISAS 1541_ GFGDL 1546_ SGLPS 1551_ GGEGL 1556_ ETSAS 1561_ EVGTD 1566_ LSGLP 1571_ SGREG 1576_ LETSA 1581_ SGAED 1586_ LSGLP 1591_ SGKED 1596_ LVGSA 1601_ SGDLD 1606_ LGKLP 1611_ SGTLG 1616_ SGQAP 1621_ ETSGL 1626_ PSGFS 1631_ GEYSG 1636_ VDLGS 1641_ GPPSG 1646_ LPDFS 1651_ GLPSG 1656_ FPTVS 1661_ LVDST 1666_ LVEVV 1671_ TASTA 1676_ SELEG 1681_ RGTIG 1686_ ISGAG 1691_ EISGL 1696_ PSSEL 1701_ DISGR 1706_ ASGLP 1711_ SGTEL 1716_ SGQAS 1721_ GSPDV 1726_ SGEIP 1731_ GLFGV 1736_ SGQPS 1741_ GFPDT 1746_ SGETS 1751_ GVTEL 1756_ SGLSS 1761_ GQPGI 1766_ SGEAS 1771_ GVLYG 1776_ TSQPF 1781_ GITDL 1786_ SGETS 1791_ GVPDL 1796_ SGQPS 1801_ GLPGF 1806_ SGATS 1811_ GVPDL 1816_ VSGTT 1821_ SGSGE 1826_ SSGIT 1831_ FVDTS 1836_ LVEVA 1841_ PTTFK 1846_ EEEGL 1851_ GSVEL 1856_ SGLPS 1861_ GEADL 1866_ SGKSG 1871_ MVDVS 1876_ GQFSG 1881_ TVDSS 1886_ GFTSQ 1891_ TPEFS 1896_ GLPSG 1901_ IAEVS 1906_ GESSR 1911_ AEIGS 1916_ SLPSG 1921_ AYYGS 1926_ GTPSS 1931_ FPTVS 1936_ LVDRT 1941_ LVESV 1946_ TQAPT 1951_ AQEAG 1956_ EGPSG 1961_ ILELS 1966_ GAHSG 1971_ APDMS 1976_ GEHSG 1981_ FLDLS 1986_ GLQSG 1991_ LIEPS 1996_ GEPPG 2001_ TPYFS 2006_ GDFAS 2011_ TTNVS 2016_ GESSV 2021_ AMGTS 2026_ GEASG 2031_ LPEVT 2036_ LITSE 2041_ FVEGV 2046_ TEPTI 2051_ SQELG 2056_ QRPPV 2061_ THTPQ 2066_ LFESS 2071_ GKVST 2076_ AGDIS 2081_ GATPV 2086_ LPGSG 2091_ VEVSS 2096_ VPESS 2101_ SETSA 2106_ YPEAG 2111_ FGASA 2116_ APEAS 2121_ REDSG 2126_ SPDLS 2131_ ETTSA 2136_ FHEAN 2141_ LERSS 2146_ GLGVS 2151_ GSTLT 2156_ FQEGE 2161_ ASAAP 2166_ EVSGE 2171_ STTTS 2176_ DVGTE 2181_ APGLP 2186_ SATPT 2191_ ASGDR 2196_ TEISG 2201_ DLSGH 2206_ TSQLG 2211_ VVIST 2216_ SIPES 2221_ EWTQQ 2226_ TQRPA 2231_ ETHLE 2236_ IESSS 2241_ LLYSG 2246_ EETHT 2251_ VETAT 2256_ SPTDA 2261_ SIPAS 2266_ PEWKR 2271_ ESEST 2276_ AAAPA 2281_ RSCAE 2286_ EPCGA 2291_ GTCKE 2296_ TEGHV 2301_ ICLCP 2306_ PGYTG 2311_ EHCNI 2316_ DQEVC 2321_ EEGWN 2326_ KYQGH 2331_ CYRHF 2336_ PDRET 2341_ WVDAE 2346_ RRCRE 2351_ QQSHL 2356_ SSIVT 2361_ PEEQE 2366_ FVNNN 2371_ AQDYQ 2376_ WIGLN 2381_ DRTIE 2386_ GDFRW 2391_ SDGHP 2396_ MQFEN 2401_ WRPNQ 2406_ PDNFF 2411_ AAGED 2416_ CVVMI 2421_ WHEKG 2426_ EWNDV 2431_ PCNYH 2436_ LPFTC 2441_ KKGTV 2446_ ACGEP 2451_ PVVEH 2456_ ARTFG 2461_ QKKDR 2466_ YEINS 2471_ LVRYQ 2476_ CTEGF 2481_ VQRHM 2486_ PTIRC 2491_ QPSGH 2496_ WEEPQ 2501_ ITCTD 2506_ PTTYK 2511_ RRLQK 2516_ RSSRH 2521_PRRSR

Protein annotations

Protein functions:

1: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region