Integrin beta-4 (GP150) (CD antigen CD104)
1_MAGPR 6_ PSPWA 11_ RLLLA 16_ ALISV 21_ SLSGT 26_ LANRC 31_ KKAPV 36_ KSCTE 41_ CVRVD 46_ KDCAY 51_ CTDEM 56_ FRDRR 61_ CNTQA 66_ ELLAA 71_ GCQRE 76_ SIVVM 81_ ESSFQ 86_ ITEET 91_ QIDTT 96_ LRRSQ 101_ MSPQG 106_ LRVRL 111_ RPGEE 116_ RHFEL 121_ EVFEP 126_ LESPV 131_ DLYIL 136_ MDFSN 141_ SMSDD 146_ LDNLK 151_ KMGQN 156_ LARVL 161_ SQLTS 166_ DYTIG 171_ FGKFV 176_ DKVSV 181_ PQTDM 186_ RPEKL 191_ KEPWP 196_ NSDPP 201_ FSFKN 206_ VISLT 211_ EDVDE 216_ FRNKL 221_ QGERI 226_ SGNLD 231_ APEGG 236_ FDAIL 241_ QTAVC 246_ TRDIG 251_ WRPDS 256_ THLLV 261_ FSTES 266_ AFHYE 271_ ADGAN 276_ VLAGI 281_ MSRND 286_ ERCHL 291_ DTTGT 296_ YTQYR 301_ TQDYP 306_ SVPTL 311_ VRLLA 316_ KHNII 321_ PIFAV 326_ TNYSY 331_ SYYEK 336_ LHTYF 341_ PVSSL 346_ GVLQE 351_ DSSNI 356_ VELLE 361_ EAFNR 366_ IRSNL 371_ DIRAL 376_ DSPRG 381_ LRTEV 386_ TSKMF 391_ QKTRT 396_ GSFHI 401_ RRGEV 406_ GIYQV 411_ QLRAL 416_ EHVDG 421_ THVCQ 426_ LPEDQ 431_ KGNIH 436_ LKPSF 441_ SDGLK 446_ MDAGI 451_ ICDVC 456_ TCELQ 461_ KEVRS 466_ ARCSF 471_ NGDFV 476_ CGQCV 481_ CSEGW 486_ SGQTC 491_ NCSTG 496_ SLSDI 501_ QPCLR 506_ EGEDK 511_ PCSGR 516_ GECQC 521_ GHCVC 526_ YGEGR 531_ YEGQF 536_ CEYDN 541_ FQCPR 546_ TSGFL 551_ CNDRG 556_ RCSMG 561_ QCVCE 566_ PGWTG 571_ PSCDC 576_ PLSNA 581_ TCIDS 586_ NGGIC 591_ NGRGH 596_ CECGR 601_ CHCHQ 606_ QSLYT 611_ DTICE 616_ INYSA 621_ IHPGL 626_ CEDLR 631_ SCVQC 636_ QAWGT 641_ GEKKG 646_ RTCEE 651_ CNFKV 656_ KMVDE 661_ LKRAE 666_ EVVVR 671_ CSFRD 676_ EDDDC 681_ TYSYT 686_ MEGDG 691_ APGPN 696_ STVLV 701_ HKKKD 706_ CPPGS 711_ FWWLI 716_ PLLLL 721_ LLPLL 726_ ALLLL 731_ LCWKY 736_ CACCK 741_ ACLAL 746_ LPCCN 751_ RGHMV 756_ GFKED 761_ HYMLR 766_ ENLMA 771_ SDHLD 776_ TPMLR 781_ SGNLK 786_ GRDVV 791_ RWKVT 796_ NNMQR 801_ PGFAT 806_ HAASI 811_ NPTEL 816_ VPYGL 821_ SLRLA 826_ RLCTE 831_ NLLKP 836_ DTREC 841_ AQLRQ 846_ EVEEN 851_ LNEVY 856_ RQISG 861_ VHKLQ 866_ QTKFR 871_ QQPNA 876_ GKKQD 881_ HTIVD 886_ TVLMA 891_ PRSAK 896_ PALLK 901_ LTEKQ 906_ VEQRA 911_ FHDLK 916_ VAPGY 921_ YTLTA 926_ DQDAR 931_ GMVEF 936_ QEGVE 941_ LVDVR 946_ VPLFI 951_ RPEDD 956_ DEKQL 961_ LVEAI 966_ DVPAG 971_ TATLG 976_ RRLVN 981_ ITIIK 986_ EQARD 991_ VVSFE 996_ QPEFS 1001_ VSRGD 1006_ QVARI 1011_ PVIRR 1016_ VLDGG 1021_ KSQVS 1026_ YRTQD 1031_ GTAQG 1036_ NRDYI 1041_ PVEGE 1046_ LLFQP 1051_ GEAWK 1056_ ELQVK 1061_ LLELQ 1066_ EVDSL 1071_ LRGRQ 1076_ VRRFH 1081_ VQLSN 1086_ PKFGA 1091_ HLGQP 1096_ HSTTI 1101_ IIRDP 1106_ DELDR 1111_ SFTSQ 1116_ MLSSQ 1121_ PPPHG 1126_ DLGAP 1131_ QNPNA 1136_ KAAGS 1141_ RKIHF 1146_ NWLPP 1151_ SGKPM 1156_ GYRVK 1161_ YWIQG 1166_ DSESE 1171_ AHLLD 1176_ SKVPS 1181_ VELTN 1186_ LYPYC 1191_ DYEMK 1196_ VCAYG 1201_ AQGEG 1206_ PYSSL 1211_ VSCRT 1216_ HQEVP 1221_ SEPGR 1226_ LAFNV 1231_ VSSTV 1236_ TQLSW 1241_ AEPAE 1246_ TNGEI 1251_ TAYEV 1256_ CYGLV 1261_ NDDNR 1266_ PIGPM 1271_ KKVLV 1276_ DNPKN 1281_ RMLLI 1286_ ENLRE 1291_ SQPYR 1296_ YTVKA 1301_ RNGAG 1306_ WGPER 1311_ EAIIN 1316_ LATQP 1321_ KRPMS 1326_ IPIIP 1331_ DIPIV 1336_ DAQSG 1341_ EDYDS 1346_ FLMYS 1351_ DDVLR 1356_ SPSGS 1361_ QRPSV 1366_ SDDTG 1371_ CGWKF 1376_ EPLLG 1381_ EELDL 1386_ RRVTW 1391_ RLPPE 1396_ LIPRL 1401_ SASSG 1406_ RSSDA 1411_ EAPHG 1416_ PPDDG 1421_ GAGGK 1426_ GGSLP 1431_ RSATP 1436_ GPPGE 1441_ HLVNG 1446_ RMDFA 1451_ FPGST 1456_ NSLHR 1461_ MTTTS 1466_ AAAYG 1471_ THLSP 1476_ HVPHR 1481_ VLSTS 1486_ STLTR 1491_ DYNSL 1496_ TRSEH 1501_ SHSTT 1506_ LPRDY 1511_ STLTS 1516_ VSSHD 1521_ SRLTA 1526_ GVPDT 1531_ PTRLV 1536_ FSALG 1541_ PTSLR 1546_ VSWQE 1551_ PRCER 1556_ PLQGY 1561_ SVEYQ 1566_ LLNGG 1571_ ELHRL 1576_ NIPNP 1581_ AQTSV 1586_ VVEDL 1591_ LPNHS 1596_ YVFRV 1601_ RAQSQ 1606_ EGWGR 1611_ EREGV 1616_ ITIES 1621_ QVHPQ 1626_ SPLCP 1631_ LPGSA 1636_ FTLST 1641_ PSAPG 1646_ PLVFT 1651_ ALSPD 1656_ SLQLS 1661_ WERPR 1666_ RPNGD 1671_ IVGYL 1676_ VTCEM 1681_ AQGGG 1686_ PATAF 1691_ RVDGD 1696_ SPESR 1701_ LTVPG 1706_ LSENV 1711_ PYKFK 1716_ VQART 1721_ TEGFG 1726_ PEREG 1731_ IITIE 1736_ SQDGG 1741_ PFPQL 1746_ GSRAG 1751_ LFQHP 1756_ LQSEY 1761_ SSITT 1766_ THTSA 1771_ TEPFL 1776_ VDGLT 1781_ LGAQH 1786_ LEAGG 1791_ SLTRH 1796_ VTQEF 1801_ VSRTL 1806_ TTSGT 1811_ LSTHM 1816_DQQFF
1: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)