Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]
1_MATLL 6_ LLLGV 11_ LVVSP 16_ DALGS 21_ TTAVQ 26_ TPTSG 31_ EPLVS 36_ TSEPL 41_ SSKMY 46_ TTSIT 51_ SDPKA 56_ DSTGD 61_ QTSAL 66_ PPSTS 71_ INEGS 76_ PLWTS 81_ IGAST 86_ GSPLP 91_ EPTTY 96_ QEVSI 101_ KMSSV 106_ PQETP 111_ HATSH 116_ PAVPI 121_ TANSL 126_ GSHTV 131_ TGGTI 136_ TTNSP 141_ ETSSR 146_ TSGAP 151_ VTTAA 156_ SSLET 161_ SRGTS 166_ GPPLT 171_ MATVS 176_ LETSK 181_ GTSGP 186_ PVTMA 191_ TDSLE 196_ TSTGT 201_ TGPPV 206_ TMTTG 211_ SLEPS 216_ SGASG 221_ PQVSS 226_ VKLST 231_ MMSPT 236_ TSTNA 241_ STVPF 246_ RNPDE 251_ NSRGM 256_ LPVAV 261_ LVALL 266_ AVIVL 271_ VALLL 276_ LWRRR 281_ QKRRT 286_ GALVL 291_ SRGGK 296_ RNGVV 301_ DAWAG 306_ PAQVP 311_ EEGAV 316_ TVTVG 321_ GSGGD 326_ KGSGF 331_ PDGEG 336_ SSRRP 341_ TLTTF 346_ FGRRK 351_ SRQGS 356_ LAMEE 361_ LKSGS 366_ GPSLK 371_ GEEEP 376_ LVASE 381_ DGAVD 386_ APAPD 391_EPEGG
1: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity)
2: Protects cells from apoptotic signals, promoting cell survival