Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)
1_MAAAL 6_ LARAS 11_ GPARR 16_ ALCPR 21_ AWRQL 26_ HTIYQ 31_ SVELP 36_ ETHQM 41_ LLQTC 46_ RDFAE 51_ KELFP 56_ IAAQV 61_ DKEHL 66_ FPAAQ 71_ VKKMG 76_ GLGLL 81_ AMDVP 86_ EELGG 91_ AGLDY 96_ LAYAI 101_ AMEEI 106_ SRGCA 111_ STGVI 116_ MSVNN 121_ SLYLG 126_ PILKF 131_ GSKEQ 136_ KQAWV 141_ TPFTS 146_ GDKIG 151_ CFALS 156_ EPGNG 161_ SDAGA 166_ ASTTA 171_ RAEGD 176_ SWVLN 181_ GTKAW 186_ ITNAW 191_ EASAA 196_ VVFAS 201_ TDRAL 206_ QNKGI 211_ SAFLV 216_ PMPTP 221_ GLTLG 226_ KKEDK 231_ LGIRG 236_ SSTAN 241_ LIFED 246_ CRIPK 251_ DSILG 256_ EPGMG 261_ FKIAM 266_ QTLDM 271_ GRIGI 276_ ASQAL 281_ GIAQT 286_ ALDCA 291_ VNYAE 296_ NRMAF 301_ GAPLT 306_ KLQVI 311_ QFKLA 316_ DMALA 321_ LESAR 326_ LLTWR 331_ AAMLK 336_ DNKKP 341_ FIKEA 346_ AMAKL 351_ AASEA 356_ ATAIS 361_ HQAIQ 366_ ILGGM 371_ GYVTE 376_ MPAER 381_ HYRDA 386_ RITEI 391_ YEGTS 396_ EIQRL 401_ VIAGH 406_LLRSY
1: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:11134486, PubMed:21237683)