Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
1_MTMES 6_ GAENQ 11_ QSGDA 16_ AVTEA 21_ ENQQM 26_ TVQAQ 31_ PQIAT 36_ LAQVS 41_ MPAAH 46_ ATSSA 51_ PTVTL 56_ VQLPN 61_ GQTVQ 66_ VHGVI 71_ QAAQP 76_ SVIQS 81_ PQVQT 86_ VQIST 91_ IAESE 96_ DSQES 101_ VDSVT 106_ DSQKR 111_ REILS 116_ RRPSY 121_ RKILN 126_ DLSSD 131_ APGVP 136_ RIEEE 141_ KSEEE 146_ TSAPA 151_ ITTVT 156_ VPTPI 161_ YQTSS 166_ GQYIA 171_ ITQGG 176_ AIQLA 181_ NNGTD 186_ GVQGL 191_ QTLTM 196_ TNAAA 201_ TQPGT 206_ TILQY 211_ AQTTD 216_ GQQIL 221_ VPSNQ 226_ VVVQA 231_ ASGDV 236_ QTYQI 241_ RTAPT 246_ STIAP 251_ GVVMA 256_ SSPAL 261_ PTQPA 266_ EEAAR 271_ KREVR 276_ LMKNR 281_ EAARE 286_ CRRKK 291_ KEYVK 296_ CLENR 301_ VAVLE 306_ NQNKT 311_ LIEEL 316_ KALKD 321_LYCHK
1: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity)