Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
1_MGTSH 6_ PAFLV 11_ LGCLL 16_ TGLSL 21_ ILCQL 26_ SLPSI 31_ LPNEN 36_ EKVVQ 41_ LNSSF 46_ SLRCF 51_ GESEV 56_ SWQYP 61_ MSEEE 66_ SSDVE 71_ IRNEE 76_ NNSGL 81_ FVTVL 86_ EVSSA 91_ SAAHT 96_ GLYTC 101_ YYNHT 106_ QTEEN 111_ ELEGR 116_ HIYIY 121_ VPDPD 126_ VAFVP 131_ LGMTD 136_ YLVIV 141_ EDDDS 146_ AIIPC 151_ RTTDP 156_ ETPVT 161_ LHNSE 166_ GVVPA 171_ SYDSR 176_ QGFNG 181_ TFTVG 186_ PYICE 191_ ATVKG 196_ KKFQT 201_ IPFNV 206_ YALKA 211_ TSELD 216_ LEMEA 221_ LKTVY 226_ KSGET 231_ IVVTC 236_ AVFNN 241_ EVVDL 246_ QWTYP 251_ GEVKG 256_ KGITM 261_ LEEIK 266_ VPSIK 271_ LVYTL 276_ TVPEA 281_ TVKDS 286_ GDYEC 291_ AARQA 296_ TREVK 301_ EMKKV 306_ TISVH 311_ EKGFI 316_ EIKPT 321_ FSQLE 326_ AVNLH 331_ EVKHF 336_ VVEVR 341_ AYPPP 346_ RISWL 351_ KNNLT 356_ LIENL 361_ TEITT 366_ DVEKI 371_ QEIRY 376_ RSKLK 381_ LIRAK 386_ EEDSG 391_ HYTIV 396_ AQNED 401_ AVKSY 406_ TFELL 411_ TQVPS 416_ SILDL 421_ VDDHH 426_ GSTGG 431_ QTVRC 436_ TAEGT 441_ PLPDI 446_ EWMIC 451_ KDIKK 456_ CNNET 461_ SWTIL 466_ ANNVS 471_ NIITE 476_ IHSRD 481_ RSTVE 486_ GRVTF 491_ AKVEE 496_ TIAVR 501_ CLAKN 506_ LLGAE 511_ NRELK 516_ LVAPT 521_ LRSEL 526_ TVAAA 531_ VLVLL 536_ VIVII 541_ SLIVL 546_ VVIWK 551_ QKPRY 556_ EIRWR 561_ VIESI 566_ SPDGH 571_ EYIYV 576_ DPMQL 581_ PYDSR 586_ WEFPR 591_ DGLVL 596_ GRVLG 601_ SGAFG 606_ KVVEG 611_ TAYGL 616_ SRSQP 621_ VMKVA 626_ VKMLK 631_ PTARS 636_ SEKQA 641_ LMSEL 646_ KIMTH 651_ LGPHL 656_ NIVNL 661_ LGACT 666_ KSGPI 671_ YIITE 676_ YCFYG 681_ DLVNY 686_ LHKNR 691_ DSFLS 696_ HHPEK 701_ PKKEL 706_ DIFGL 711_ NPADE 716_ STRSY 721_ VILSF 726_ ENNGD 731_ YMDMK 736_ QADTT 741_ QYVPM 746_ LERKE 751_ VSKYS 756_ DIQRS 761_ LYDRP 766_ ASYKK 771_ KSMLD 776_ SEVKN 781_ LLSDD 786_ NSEGL 791_ TLLDL 796_ LSFTY 801_ QVARG 806_ MEFLA 811_ SKNCV 816_ HRDLA 821_ ARNVL 826_ LAQGK 831_ IVKIC 836_ DFGLA 841_ RDIMH 846_ DSNYV 851_ SKGST 856_ FLPVK 861_ WMAPE 866_ SIFDN 871_ LYTTL 876_ SDVWS 881_ YGILL 886_ WEIFS 891_ LGGTP 896_ YPGMM 901_ VDSTF 906_ YNKIK 911_ SGYRM 916_ AKPDH 921_ ATSEV 926_ YEIMV 931_ KCWNS 936_ EPEKR 941_ PSFYH 946_ LSEIV 951_ ENLLP 956_ GQYKK 961_ SYEKI 966_ HLDFL 971_ KSDHP 976_ AVARM 981_ RVDSD 986_ NAYIG 991_ VTYKN 996_ EEDKL 1001_ KDWEG 1006_ GLDEQ 1011_ RLSAD 1016_ SGYII 1021_ PLPDI 1026_ DPVPE 1031_ EEDLG 1036_ KRNRH 1041_ SSQTS 1046_ EESAI 1051_ ETGSS 1056_ SSTFI 1061_ KREDE 1066_ TIEDI 1071_ DMMDD 1076_ IGIDS 1081_SDLVE
1: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor