Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1)
1_MPGFL 6_ VRILP 11_ LLLVL 16_ LLLGP 21_ TRGLR 26_ NATQR 31_ MFEID 36_ YSRDS 41_ FLKDG 46_ QPFRY 51_ ISGSI 56_ HYSRV 61_ PRFYW 66_ KDRLL 71_ KMKMA 76_ GLNAI 81_ QTYVP 86_ WNFHE 91_ PWPGQ 96_ YQFSE 101_ DHDVE 106_ YFLRL 111_ AHELG 116_ LLVIL 121_ RPGPY 126_ ICAEW 131_ EMGGL 136_ PAWLL 141_ EKESI 146_ LLRSS 151_ DPDYL 156_ AAVDK 161_ WLGVL 166_ LPKMK 171_ PLLYQ 176_ NGGPV 181_ ITVQV 186_ ENEYG 191_ SYFAC 196_ DFDYL 201_ RFLQK 206_ RFRHH 211_ LGDDV 216_ VLFTT 221_ DGAHK 226_ TFLKC 231_ GALQG 236_ LYTTV 241_ DFGTG 246_ SNITD 251_ AFLSQ 256_ RKCEP 261_ KGPLI 266_ NSEFY 271_ TGWLD 276_ HWGQP 281_ HSTIK 286_ TEAVA 291_ SSLYD 296_ ILARG 301_ ASVNL 306_ YMFIG 311_ GTNFA 316_ YWNGA 321_ NSPYA 326_ AQPTS 331_ YDYDA 336_ PLSEA 341_ GDLTE 346_ KYFAL 351_ RNIIQ 356_ KFEKV 361_ PEGPI 366_ PPSTP 371_ KFAYG 376_ KVTLE 381_ KLKTV 386_ GAALD 391_ ILCPS 396_ GPIKS 401_ LYPLT 406_ FIQVK 411_ QHYGF 416_ VLYRT 421_ TLPQD 426_ CSNPA 431_ PLSSP 436_ LNGVH 441_ DRAYV 446_ AVDGI 451_ PQGVL 456_ ERNNV 461_ ITLNI 466_ TGKAG 471_ ATLDL 476_ LVENM 481_ GRVNY 486_ GAYIN 491_ DFKGL 496_ VSNLT 501_ LSSNI 506_ LTDWT 511_ IFPLD 516_ TEDAV 521_ RSHLG 526_ GWGHR 531_ DSGHH 536_ DEAWA 541_ HNSSN 546_ YTLPA 551_ FYMGN 556_ FSIPS 561_ GIPDL 566_ PQDTF 571_ IQFPG 576_ WTKGQ 581_ VWING 586_ FNLGR 591_ YWPAR 596_ GPQLT 601_ LFVPQ 606_ HILMT 611_ SAPNT 616_ ITVLE 621_ LEWAP 626_ CSSDD 631_ PELCA 636_ VTFVD 641_ RPVIG 646_ SSVTY 651_ DHPSK 656_ PVEKR 661_ LMPPP 666_ PQKNK 671_DSWLD
1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans
2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers